Evidence map›Paper›PMID 34335258›Full record

ArticleFrontiers in pharmacology2021

Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma.

Zhong-Kun Xia, Wei Wang, Jian-Ge Qiu, Xi-Nan Shi, Hong-Jian Li, Rong Chen, Kun-Bin Ke, Chao Dong, Ying Zhu, Shi-Guo Wu and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 2 countries.

Zhong-Kun XiaSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Wei WangSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Jian-Ge QiuSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Xi-Nan ShiDepartment of Pathology, Yunnan University of Chinese Medicine, Kunming, China.
Hong-Jian LiCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.
Rong ChenDepartment of Physiology, Yunnan University of Chinese Medicine, Kunming, China.
Kun-Bin KeDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Chao DongDepartment of the Second Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Tumor Hospital, Kunming, China.
Ying ZhuDepartment of Cadre Medical Branch, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Shi-Guo WuDepartment of Teaching and Research Section of Formulas of Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Rong-Ping ZhangSchool of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine,Kunming, China.
Zhuo-Ran MengDepartment of Pathology, Yunnan University of Chinese Medicine, Kunming, China.
Hui ZhaoDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Peng GuDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Kwong-Sak LeungDepartment of Computer Science and Engineering, Chinese University of Hong Kong, Hong Kong, China.
Man-Hon WongDepartment of Computer Science and Engineering, Chinese University of Hong Kong, Hong Kong, China.
Xiao-Dong LiuDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Feng-Mei ZhouSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Jian-Ying ZhangSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Ya-Ting YaoSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Si-Jia WangSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Chun-Yang ZhangCollege of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China.
Yan-Ru QinDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Marie Chia-Mi LinSchool of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Bing-Hua JiangDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Zhengzhou University · CNKunming Medical University · CNChinese University of Hong Kong · CNYunnan University · CNFirst Affiliated Hospital of Kunming Medical University · CNYunnan University of Traditional Chinese Medicine · CNFirst Affiliated Hospital of Zhengzhou University · CNShandong Normal University · CNThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

aminoquinolCDK4/6hepatocellular carcinomaPI3KRB

Identifiers

PMID34335258
PMCPMC8320333
OpenAlexW3185817805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.