Evidence map›Paper›PMID 34335235›Full record

ArticleFrontiers in aging neuroscience2021

Estrogen Deficiency Induces Mitochondrial Damage Prior to Emergence of Cognitive Deficits in a Postmenopausal Mouse Model.

Wei Zhao, Yue Hou, Xinxin Song, Lei Wang, Fangfang Zhang, Hanting Zhang, Haiyang Yu, Yanmeng Zhou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

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  6. Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wei ZhaoInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Yue HouInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Xinxin SongInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Lei WangInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Fangfang ZhangInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Hanting ZhangDepartments of Neuroscience and Behavioral Medicine and Psychiatry, Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV, United States.
Haiyang YuInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Yanmeng ZhouInstitute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Shandong First Medical University · CNBlanchette Rockefeller Neurosciences Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cognitive functionestrogenhippocampusmitochondrial biogenesismitochondrial dynamicsmitophagyovariectomy

Identifiers

PMID34335235
PMCPMC8319728
OpenAlexW3185944848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.