Evidence map›Paper›PMID 34335181›Full record

ReviewFrontiers in molecular neuroscience2021

Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research.

Melanie J Grubisha, Robert A Sweet, Matthew L MacDonald

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Melanie J GrubishaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Robert A SweetDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Matthew L MacDonaldDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
University of Pittsburgh · US

Funding

Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental IllnessR01MH125235 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEVLIN, BERNIE, MACDONALD, MATTHEW L · 2021 to 2024
$3.0M
Synaptic Protein Networks, Genetic Risk, and Spine Loss in SchizophreniaR01MH118497 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MACDONALD, MATTHEW L · 2019 to 2023
$2.5M
Enhanced NGR/p75/KAL9 Signaling and Impaired Dendritic Morphogenesis in Schizophrenia - SupplementK08MH118513 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRUBISHA, MELANIE JEAN · 2019 to 2023
$805k
ATP1A3 Induced Alterations to Glutamate Signaling Protein Networks in SchizophreniaK01MH107756 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MACDONALD, MATTHEW L · 2015 to 2018
$631k
NIMH NIH HHS K01 MH107756NIMH NIH HHS K08 MH118513NIMH NIH HHS R01 MH118497NIMH NIH HHS R01 MH125235
6 · The paper itself

Abstract

Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.

Indexed as

autismpost-mortem brainpost-translational modificationproteomicspsychiatric diseaseschizophrenia

Identifiers

PMID34335181
PMCPMC8322442
OpenAlexW3186172686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.