Evidence map›Paper›PMID 34335089›Full record

ArticleMediators of inflammation2021

Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling.

Qiang Zheng, Hang Zhao, Dong Jia, Xu Han, Zhenning Liu, Min Zhao

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qiang ZhengDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.ORCID https://orcid.org/0000-0003-4886-4337
Hang ZhaoDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.ORCID https://orcid.org/0000-0002-4143-1224
Dong JiaDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.ORCID https://orcid.org/0000-0002-2361-0739
Xu HanDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.ORCID https://orcid.org/0000-0001-6581-1136
Zhenning LiuDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.ORCID https://orcid.org/0000-0002-3606-9005
Min ZhaoDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.ORCID https://orcid.org/0000-0001-7568-6172
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefined. This study was aimed at understanding the role and mechanism of TOLLIP in AKI. Six-eight-week-old male Wistar rats were intraperitoneally injected with 25 mg/kg PQ to induce AKI for 24 h

Indexed as

Acute Kidney InjuryNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsInflammasomesIntracellular Signaling Peptides and ProteinsMaleNF-kappa BParaquatRatsRats, WistarToll-Like Receptor 2InflammasomesIntracellular Signaling Peptides and ProteinsNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratParaquattollip protein, ratToll-Like Receptor 2

Identifiers

PMID34335089
PMCPMC8298172
OpenAlexW3182374458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.