Evidence map›Paper›PMID 34334952›Full record

ArticleDiamond and related materials2021

Boron doped diamond thin films for the electrochemical detection of SARS-CoV-2 S1 protein.

Suzanne Witt, Alexis Rogien, Diana Werner, James Siegenthaler, Raymond Lesiyon, Noelle Kurien, Robert Rechenberg, Nina Baule, Aaron Hardy, Michael Becker

Open access · greenAbstract read
In one paragraph

Article in Diamond and related materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Suzanne WittFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Alexis RogienFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Diana WernerFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
James SiegenthalerFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Raymond LesiyonFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Noelle KurienFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Robert RechenbergFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Nina BauleFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Aaron HardyFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Michael BeckerFraunhofer USA, Center Midwest, 1449 Engineering Research Ct., East Lansing, MI 48824, USA.
Fraunhofer USA · USMichigan State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amidst a global pandemic, a precise and widely accessible rapid detection method is needed for accurate diagnosis and contact tracing. The lack of this technology was exposed through the outbreak of SARS-CoV-2 beginning in 2019. This study sets the foundation for the development of a boron doped diamond (BDD)-based impedimetric sensor. While specifically developed for use in the detection of SARS-CoV-2, this technology uses principles that could be adapted to detect other viruses in the future. Boron doped polycrystalline diamond electrodes were functionalized with a biotin-streptavidin linker complex and biotinylated anti-SARS-CoV-2 S1 antibodies. Electrodes were then incubated with the S1 subunit of the SARS-CoV-2 spike surface protein, and an electrical response was recorded using the changes to the electrode's charge transfer resistance (R

Indexed as

BiosensorBoron doped diamondImpedimetric sensorSARS-CoV-2

Identifiers

PMID34334952
PMCPMC8316675
OpenAlexW3188880172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.