Evidence map›Paper›PMID 34334563›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Progressive Cytopenia Developing during Treatment of Cryptococcosis in a Patient with HIV Infection and Bone Marrow Cryptococcal Infection.

Mai Katsura, Ayako Okuhama, Yoshiki Koizumi, Naokatsu Ando, Yasuaki Yanagawa, Daisuke Mizushima, Takahiro Aoki, Kunihisa Tsukada, Katsuji Teruya, Yoshimi Kikuchi and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Mai KatsuraAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Ayako OkuhamaAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Yoshiki KoizumiAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Naokatsu AndoAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Yasuaki YanagawaAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Daisuke MizushimaAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Takahiro AokiAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Kunihisa TsukadaAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Katsuji TeruyaAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Yoshimi KikuchiAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Shinichi OkaAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
Koji WatanabeAIDS Clinical Center of the National Center for Global Health and Medicine, Japan.
National Center for Global Health and Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytopenia is a common complication in patients with human immunodeficiency virus (HIV) infection. Identifying the cause is demanding because of the wide range of possible diagnoses. We herein report an HIV-infected patient with disseminated cryptococcosis involving multiple organs including the blood, brain, lungs, and bone marrow, who developed progressive pancytopenia after initiation of anti-fungal treatment with liposomal amphotericin-B (L-AMB) and flucytosine (5FC). The pancytopenia persisted despite early 5FC discontinuation. A bone marrow biopsy revealed cryptococcal infiltration and the blood examination findings recovered quickly after resuming L-AMB. Thus, this HIV-infected patient's pathological findings and clinical course suggested that the primary cause of the pancytopenia was bone marrow cryptococcosis.

Indexed as

CryptococcosisCryptococcus neoformansHIV InfectionsMeningitis, CryptococcalAntifungal AgentsBone MarrowFlucytosineHumansAntifungal AgentsFlucytosineadrenal insufficiencyCryptococcuscytopeniaHIV

Identifiers

PMID34334563
PMCPMC8851175
OpenAlexW3190905581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.