Evidence map›Paper›PMID 34334369›Full record

ArticleMolecular pharmacology2021

Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting

Christopher T Szlenk, Jeevan B Gc, Senthil Natesan

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Allosteric modulation of α1β3γ2 GABABiophysical journal · 2023
    Article
  6. Characterization of a novel positive allosteric modulator of the αCurrent research in pharmacology and drug discovery · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher T SzlenkDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Jeevan B GcDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Senthil NatesanDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington senthil.natesan@wsu.edu.
Washington State University Spokane · US

Funding

Molecular biophysics of integrin activation by oxysterols and rational discovery of small-molecule modulatorsR01GM137022 · NIGMS · WASHINGTON STATE UNIVERSITY · PI NATESAN, SENTHIL KUMAR · 2020 to 2023
$1.2M
Specifics of "Non-Specific Membrane Interactions" of Drugs: An Integrated Approach for Understanding Structure-Membrane Interaction RelationshipsR15GM131293 · NIGMS · WASHINGTON STATE UNIVERSITY · PI NATESAN, SENTHIL KUMAR · 2018 to 2018
$458k
NIGMS NIH HHS R01 GM137022NIGMS NIH HHS R15 GM131293
6 · The paper itself

Abstract

The drugs salmeterol, formoterol, and salbutamol constitute the frontline treatment of asthma and other chronic pulmonary diseases. These drugs activate the

Indexed as

Adrenergic beta-2 Receptor AgonistsAlbuterolBinding SitesCell MembraneDelayed-Action PreparationsFormoterol FumarateHumansMolecular Docking SimulationProtein BindingProtein Structure, SecondaryProtein Structure, TertiarySalmeterol XinafoateAdrenergic beta-2 Receptor AgonistsAlbuterolDelayed-Action PreparationsFormoterol FumarateSalmeterol Xinafoate

Identifiers

PMID34334369
PMCPMC8626642
OpenAlexW3188003199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.