Evidence map›Paper›PMID 34334160›Full record

Observational studyJournal of the American Medical Directors Association2021

Predicting Mortality Risk in Older Hospitalized Persons With COVID-19: A Comparison of the COVID-19 Mortality Risk Score with Frailty and Disability.

Carlo Fumagalli, Andrea Ungar, Renzo Rozzini, Matteo Vannini, Flaminia Coccia, Giulia Cesaroni, Francesca Mazzeo, Nicoletta D'Ettore, Chiara Zocchi, Luigi Tassetti and 8 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Medical Directors Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  7. Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carlo FumagalliDepartment of Experimental and Clinical Medicine, University of Florence, Italy. Electronic address: carlo.fumagalli@unifi.it.
Andrea UngarDepartment of Experimental and Clinical Medicine, University of Florence, Italy.
Renzo RozziniDepartment of Geriatrics and Internal Medicine, Poliambulanza Hospital, Brescia, Italy.
Matteo VanniniDepartment of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Flaminia CocciaDepartment of Geriatrics and Internal Medicine, Poliambulanza Hospital, Brescia, Italy.
Giulia CesaroniDepartment of Geriatrics and Internal Medicine, Poliambulanza Hospital, Brescia, Italy.
Francesca MazzeoDepartment of Geriatrics and Internal Medicine, Poliambulanza Hospital, Brescia, Italy.
Nicoletta D'EttoreDepartment of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Chiara ZocchiDepartment of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Luigi TassettiDepartment of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Alessandro BartoloniDepartment of Internal and Emergency Medicine, Careggi Hospital, Florence, Italy.
Federico LavoriniDepartment of Experimental and Clinical Medicine, University of Florence, Italy; Department of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Rossella MarcucciDepartment of Experimental and Clinical Medicine, University of Florence, Italy; Department of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Iacopo OlivottoDepartment of Experimental and Clinical Medicine, University of Florence, Italy; Department of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Laura RaseroDepartment of Public Health, University of Florence, Florence, Italy.
Francesco FattirolliDepartment of Experimental and Clinical Medicine, University of Florence, Italy; Department of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.
Stefano FumagalliDepartment of Experimental and Clinical Medicine, University of Florence, Italy.
Niccolò MarchionniDepartment of Experimental and Clinical Medicine, University of Florence, Italy; Department of Cardiothoracovascular Medicine, Careggi Hospital, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the association of pre-morbid functional status [Barthel Index (BI)] and frailty [modified Frailty Index (mFI)] with in-hospital mortality and a risk scoring system developed for COVID-19 in patients ≥75 years diagnosed with COVID-19.

designRetrospective bicentric observational study. SETTING AND

participantsData on consecutive patients aged ≥75 years admitted with COVID-19 at 2 Italian tertiary care centers were collected from February 22 to May 30, 2020.

methodsOverall, 221 consecutive patients with COVID-19 aged ≥75 years were admitted to 2 hospitals in the study period and were included in the analysis. Clinical, functional (BI), frailty (mFI), laboratory, and imaging data were collected. Mortality risk on admission was assessed with the COVID-19 Mortality Risk Score (COVID-19 MRS), a dedicated score developed for hospital triage.

resultsNinety-seven (43.9%) patients died. BI, frailty, age, dementia, respiratory rate, Pao CONCLUSIONS AND IMPLICATIONS: Premorbid BI and mFI are associated with mortality and improved the accuracy of the COVID-19 MRS. Functional status may prove useful to guide clinical management of older individuals.

Indexed as

COVID-19FrailtyAgedHospital MortalityHumansItalyRetrospective StudiesRisk FactorsSARS-CoV-2COVID-19geriatricsinfectious diseaseintensive careintensive care medicine

Identifiers

PMID34334160
PMCPMC8249822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.