Evidence map›Paper›PMID 34334136›Full record

ArticleJournal of pharmaceutical health care and sciences2021

Anorexia, pain and peripheral neuropathy are associated with a decrease in quality of life in patients with advanced pancreatic cancer receiving outpatient chemotherapy - a retrospective observational study.

Hironori Fujii, Maaya Koda, Shiori Sadaka, Koichi Ohata, Hiroko Kato-Hayashi, Hirotoshi Iihara, Ryo Kobayashi, Takuma Ishihara, Shinya Uemura, Takuji Iwashita and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical health care and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Hironori FujiiDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan. h_fujii@gifu-u.ac.jp.
Maaya KodaLaboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
Shiori SadakaDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.
Koichi OhataDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.
Hiroko Kato-HayashiDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.
Hirotoshi IiharaDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.
Ryo KobayashiDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.
Takuma IshiharaGifu University Hospital, Innovative and Clinical Research Promotion Center, Gifu University, Gifu, 501-1194, Japan.
Shinya UemuraFirst Department of Internal Medicine, Gifu University Hospital, Gifu, 501-1194, Japan.
Takuji IwashitaFirst Department of Internal Medicine, Gifu University Hospital, Gifu, 501-1194, Japan.
Hideki HayashiLaboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
Tadashi SugiyamaLaboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
Masahito ShimizuFirst Department of Internal Medicine, Gifu University Hospital, Gifu, 501-1194, Japan.
Akio SuzukiDepartment of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.
Gifu University Hospital · JPGifu Pharmaceutical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between moderate-to-severe AEs and quality of life (QOL) in patients with APC who received outpatient chemotherapy.

methodsWe recruited APC patients who received outpatient chemotherapy in Gifu University Hospital between September 2017 and December 2018. Adverse events related to chemotherapy were assessed by a pharmacist collaborating with a physician using common terminology criteria for AEs (CTCAE) ver 4.0, and QOL of patients was self-assessed by patients using the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L Japanese edition 2). Associations between the EQ-5D-5L utility value and serious AEs were assessed using proportional odds logistic regression.

resultsA total of 59 patients who received 475 chemotherapy cycles were included. The proportional odds logistic regression indicated that grade ≥ 2 anorexia, pain and peripheral neuropathy were significantly correlated with a decreased EQ-5D-5L utility value. Pharmaceutical intervention for these AEs significantly improved the patients' EQ-5D-5L utility value.

conclusionsAnorexia, pain and peripheral neuropathy were significantly associated with a decrease in QOL. It is assumed that appropriate pharmaceutical intervention with particular emphasis on these AEs can improve the QOL of pancreatic cancer patients receiving outpatient chemotherapy.

Indexed as

Adverse events related outpatient cancer chemotherapyPancreatic cancerProportional odds logistic regression modelQuality of lifeRetrospective observational study

Identifiers

PMID34334136
PMCPMC8327438
OpenAlexW3191027638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.