ArticleBrain and behavior2021
Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dynamic functional connectivity changes in the triple networks in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.Quantitative imaging in medicine and surgery · 2026Article
- Altered brain entropy and functional connectivity patterns in peritoneal dialysis patients.Frontiers in neuroscience · 2026Article
- Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus.Frontiers in neuroscience · 2026Article
- Cognitive impairment assessed by static and dynamic changes of spontaneous brain activity during end stage renal disease patients on early hemodialysis.Frontiers in neurology · 2025Article
- Abnormal dynamic functional connectivity in young nondisabling intracerebral hemorrhage patients.Annals of clinical and translational neurology · 2024Article
- Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease.Renal failure · 2023Article
- Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease.Frontiers in neuroscience · 2022Article
- Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients.Brain and behavior · 2021Article
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7 authors.
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Abstract
introductionCognitive impairment is common in hemodialysis (HD) patients; however, the underlying mechanisms have not been fully understood. The "triple-network model" that consists of the salience network (SN), central executive network (CEN), and default mode network (DMN) has been suggested to play an important role in various cognitive functions. However, dynamic functional connectivity (FC) alterations within the triple networks have not been investigated in HD patients.
methodsSixty-six HD patients and 66 healthy controls (HCs) were included in this study. The triple networks were identified using a group spatial independent component analysis, and dynamic FC was analyzed using a sliding window approach and k-means clustering algorithm. Furthermore, we analyzed the relationships between altered dynamic FC parameters and clinical variables in HD patients.
resultsThe intrinsic brain FC within the triple networks was clustered into four configuration states. Compared with HCs, HD patients spent more time in State 1, which was characterized by weak connections between the DMN and CEN and SN. HD patients showed lower number of transitions across different states than HCs. Moreover, the number of transitions and mean dwell time in State 1 were associated with cognitive performance in HD patients.
conclusionOur findings suggest abnormal dynamic FC properties within the triple networks in HD patients, which may provide new insights into the pathophysiological mechanisms of their cognitive deficits from the perspective of dynamic FC.
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