Evidence map›Paper›PMID 34333729›Full record

ArticleDrug delivery and translational research2022

Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting.

Ruchika Goyal, Gaurav Jerath, Aneesh Chandrasekharan, Yvonne Christian, T R Santhosh Kumar, Vibin Ramakrishnan

Erratum issuedAbstract read
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In one paragraph

Article in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ruchika GoyalDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Gaurav JerathDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Aneesh ChandrasekharanRajiv Gandhi Centre for Biotechnology, Cancer Research Program-1, Thiruvananthapuram, 695014, Kerala, India.
Yvonne ChristianDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
T R Santhosh KumarRajiv Gandhi Centre for Biotechnology, Cancer Research Program-1, Thiruvananthapuram, 695014, Kerala, India.
Vibin RamakrishnanDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India. vibin@iitg.ac.in.ORCID 0000-0002-8048-3211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and cytotoxicity evaluation. The differential uptake, cellular internalization, negligible hemotoxicity, selective toxicity to MDA-MB-231 breast cancer cells, and the superior penetration in three-dimensional MDA-MB-231 tumorospheres confirm their utility as a promising delivery vector.

Indexed as

Antineoplastic AgentsCell-Penetrating PeptidesCell Line, TumorDrug Delivery SystemsProtein DomainsAntineoplastic AgentsCell-Penetrating PeptidesCell-penetrating peptideDrug deliveryDrug designTumor homing peptide

Identifiers

PMID34333729

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.