Evidence map›Paper›PMID 34333291›Full record

ReviewEnvironment international2021

Mechanisms underlying the health effects of desert sand dust.

Julia C Fussell, Frank J Kelly

Open access · goldAbstract readReview
In one paragraph

Review in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Kawasaki disease and outdoor environmental stressors: a scoping review.The Lancet regional health. Western Pacific · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Air Pollution and Global Pediatric Pneumococcal Disease.Open forum infectious diseases · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julia C FussellNational Institute for Health Research Health Protection Research Unit in Environmental Exposures and Health, School of Public Health, Sir Michael Uren Building, Imperial College London, White City Campus, 80-92 Wood Lane, London W12 0BZ, United Kingdom. Electronic address: julia.fussell@imperial.ac.uk.
Frank J KellyNational Institute for Health Research Health Protection Research Unit in Environmental Exposures and Health, School of Public Health, Sir Michael Uren Building, Imperial College London, White City Campus, 80-92 Wood Lane, London W12 0BZ, United Kingdom.
Imperial College London · GB

Funding

Department of HealthMedical Research Council MR/S0196669/1Medical Research Council MR/S019669/1Wellcome Trust 209376/Z/17/Z
6 · The paper itself

Abstract

Desertification and climate change indicate a future expansion of the global area of dry land and an increase in the risk of drought. Humans may therefore be at an ever-increasing risk of frequent exposure to, and resultant adverse health effects of desert sand dust. This review appraises a total of 52 experimental studies that have sought to identify mechanisms and intermediate endpoints underlying epidemiological evidence of an impact of desert dust on cardiovascular and respiratory health. Toxicological studies, in main using doses that reflect or at least approach real world exposures during a dust event, have demonstrated that virgin sand dust particles and dust storm particles sampled at remote locations away from the source induce inflammatory lung injury and aggravate allergen-induced nasal and pulmonary eosinophilia. Effects are orchestrated by cytokines, chemokines and antigen-specific immunoglobulin potentially via toll-like receptor/myeloid differentiation factor signaling pathways. Findings suggest that in addition to involvement of adhered chemical and biological pollutants, mineralogical components may also be implicated in the pathogenesis of human respiratory disorders during a dust event. Whilst comparisons with urban particulate matter less than 2.5 μm in diameter (PM

Indexed as

Air PollutantsDustAerosolsHumansParticulate MatterSandAerosolsAir PollutantsDustParticulate MatterSandAllergic respiratory diseaseAsian sand dustCardiovascular diseaseDesert dustInflammationMicrobial materialsOxidative stressToxicology

Identifiers

PMID34333291
PMCPMC8484861
OpenAlexW3187896165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.