Evidence map›Paper›PMID 34333006›Full record

ArticleInternational journal of biological macromolecules2021

Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL

Yuan Xiong, Guang-Hao Zhu, Ya-Ni Zhang, Qing Hu, Hao-Nan Wang, Hao-Nan Yu, Xiao-Ya Qin, Xiao-Qing Guan, Yan-Wei Xiang, Hui Tang and 1 more

Open access · greenAbstract read
In one paragraph

Article in International journal of biological macromolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Uncovering the covalent inhibitors of SARS-CoV-2 MJournal of pharmaceutical analysis · 2026
    Article
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  4. Identification of broad-spectrum MJournal of enzyme inhibition and medicinal chemistry · 2025
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  7. The near-complete genome assembly ofFrontiers in plant science · 2025
    Article
  8. Article
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  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yuan XiongShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang, China.
Guang-Hao ZhuShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ya-Ni ZhangShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qing HuShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hao-Nan WangShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hao-Nan YuShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiao-Ya QinKey Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang, China.
Xiao-Qing GuanShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan-Wei XiangSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Hui TangKey Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang, China. Electronic address: th_pha@shzu.edu.cn.
Guang-Bo GeShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: geguangbo@dicp.ac.cn.
Shanghai University of Traditional Chinese Medicine · CNShihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus 3C-like protease (3CL

Indexed as

3C Viral ProteasesAmpelopsisAntiviral AgentsBinding SitesCysteineFlavonoidsFlavonolsMass SpectrometryModels, MolecularMolecular Docking SimulationMolecular Dynamics SimulationPlant ExtractsProtease InhibitorsProtein BindingProtein ConformationSARS-CoV-23C Viral ProteasesAntiviral AgentsCysteinedihydromyricetinFlavonoidsFlavonolsmyricetinPlant ExtractsProtease InhibitorsAmpelopsis grossedentata extractCovalent inhibitorsSARS-CoV-2 3CL(pro)

Identifiers

PMID34333006
PMCPMC8322037
OpenAlexW3189530923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.