Evidence map›Paper›PMID 34332999›Full record

ArticleMetabolism: clinical and experimental2021

Diabetic ketoacidosis in pediatric patients with type 1- and type 2 diabetes during the COVID-19 pandemic.

Charlotte Loh, Paul Weihe, Nicole Kuplin, Kerstin Placzek, Susann Weihrauch-Blüher

Open access · bronzeAbstract read
In one paragraph

Article in Metabolism: clinical and experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charlotte LohClinic for Pediatrics I, Pediatric Endocrinology, University Hospital Halle (Saale), Germany.
Paul WeiheClinic for Pediatrics I, Pediatric Endocrinology, University Hospital Halle (Saale), Germany.
Nicole KuplinClinic for Pediatrics I, Pediatric Endocrinology, University Hospital Halle (Saale), Germany.
Kerstin PlaczekClinic for Pediatrics I, Pediatric Endocrinology, University Hospital Halle (Saale), Germany.
Susann Weihrauch-BlüherClinic for Pediatrics I, Pediatric Endocrinology, University Hospital Halle (Saale), Germany. Electronic address: susann.weihrauch-blueher@uk-halle.de.
University Hospital in Halle · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19 pandemic caused families to stay home and cancel everyday activities. Hospital admissions decreased, affecting changes in diagnoses and management of chronic disease in children.

aimsWe analyzed how the first lockdown influenced clinical presentation and manifestation of children with diabetes mellitus (DM) in a German University Hospital.

methodsDuring March 15th and October 11th 2020, data on general patient information, clinical symptoms and on lab results related to diabetic ketoacidosis (DKA) were analyzed in children (0-18 years) who presented with new onset of DM or poor metabolic control of known DM. All data including frequency and severity of DKA were compared to data from patients who presented in 2019.

resultsData from 125 participants with DM were evaluated (2020: n = 52; 2019: n = 73). In 2020, twelve patients (23.1%) were diagnosed with new onset DM, two of them with type2 diabetes, and 66.7% presented with DKA including both patients T2DM. In 2019, 24.5% of patients had new onset DM, and 50% of them presented with DKA. In 2020, patients with new onset DM were younger, presented with more severe symptoms of DKA and had to stay longer in hospital compared to 2019. In 2020, six children (50%) with new onset DM were <6 years, whereas in 2019 most children with new onset DM were adolescents (n = 7, 38.9%).

conclusionCOVID-19 lockdown aggravated complications of diabetes onset and therapy management, including severity and frequency of DKA. It underlines the need of health education for early DKA diagnosis to early identify children at risk.

Indexed as

PandemicsAdolescentAdultChildCOVID-19Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisFemaleHumansMaleYoung AdultChildrenCOVID-19Diabetes mellitusDiabetic ketoacidosisLockdown

Identifiers

PMID34332999
PMCPMC9188025
OpenAlexW3188845202

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.