Evidence map›Paper›PMID 34332543›Full record

ArticleBMC infectious diseases2021

Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis.

Newton Kalata, Jayne Ellis, Laura Benjamin, Samuel Kampondeni, Peter Chiodini, Thomas Harrison, David G Lalloo, Robert S Heyderman

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Newton KalataMalawi Liverpool Wellcome Trust Clinical Research Programme, Liverpool, UK. nkalata@mlw.mw.ORCID http://orcid.org/0000-0003-1715-8093
Jayne EllisMalawi Liverpool Wellcome Trust Clinical Research Programme, Liverpool, UK.
Laura BenjaminStroke Research Centre, Institute of Neurology, University College London, London, UK.
Samuel KampondeniInternal Medicine Department, College of Medicine University of Malawi, Malawi, UK.
Peter ChiodiniHospital for Tropical Diseases, UCLH, London, UK.
Thomas HarrisonDivision of Infectious Disease Immunology, St George Hospital, London, UK.
David G LallooMalawi Liverpool Wellcome Trust Clinical Research Programme, Liverpool, UK.
Robert S HeydermanMalawi Liverpool Wellcome Trust Clinical Research Programme, Liverpool, UK.
University of Liverpool · GBHospital for Tropical Diseases · GBSt George's Hospital · GBUniversity of Malawi · MW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManaging HIV-associated cryptococcal meningitis (CM) can become challenging in the presence of concurrent unusual central nervous system infections. CASE PRESENTATION: A 58-year old HIV infected woman new ART starter, who was being treated effectively for cryptococcal meningitis, represented with worsening of neurological symptoms. Brain MRI revealed a multicystic lesion in the left temporal lobe. Anti-fungal treatment was escalated for a suspected cryptococcoma, but post-mortem CSF serological test confirmed racemose neurocysticercosis.

conclusionPatients with HIV-associated CM are highly immunocompromised and may have multiple pathologies simultaneously. In endemic countries, neurocysticercosis should be considered in the differential diagnosis where there is central nervous system deterioration despite effective therapy for CM.

Indexed as

HIV InfectionsMeningitis, CryptococcalNeurocysticercosisAntifungal AgentsFemaleHumansMagnetic Resonance ImagingMiddle AgedAntifungal AgentsCryptococcal meningitisHIVRacemose neurocysticercosis

Identifiers

PMID34332543
PMCPMC8325865
OpenAlexW3190611856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.