Evidence map›Paper›PMID 34332220›Full record

ArticleNeurobiology of aging2021

Age affects white matter microstructure and episodic memory across the older adult lifespan.

Jenna L Merenstein, María M Corrada, Claudia H Kawas, Ilana J Bennett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jenna L MerensteinDepartment of Psychology, University of California, Riverside, CA, USA. Electronic address: jklip001@ucr.edu.
María M CorradaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA; Department of Neurology, University of California, Irvine, CA, USA; Department of Epidemiology, University of California, Irvine, CA, USA.
Claudia H KawasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA; Department of Neurology, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Ilana J BennettDepartment of Psychology, University of California, Riverside, CA, USA.
University of California, Irvine · USUniversity of California, Riverside · US

Funding

Diversity Supplement to R01AG021055; Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ StudyR01AG021055 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CORRADA, MARIA, KAWAS, CLAUDIA H. · 2002 to 2024
$36.9M
Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
High-resolution multimodal imaging of episodic memory networks in aging.R00AG047334 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BENNETT, ILANA JACQUELINE · 2016 to 2018
$737k
Multi-compartment diffusion imaging of hippocampal white and gray matter in agingR21AG054804 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BENNETT, ILANA JACQUELINE · 2017 to 2018
$427k
Structural and functional substrates of associative memory load in agingF31AG071189 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MERENSTEIN, JENNA L · 2021 to 2022
$58k
NIA NIH HHS F31 AG071189NIA NIH HHS R00 AG047334NIA NIH HHS R01 AG021055NIA NIH HHS R01 AG053555NIA NIH HHS R21 AG054804
6 · The paper itself

Abstract

Diffusion imaging studies have observed age-related degradation of white matter that contributes to cognitive deficits separately in younger-old (ages 65-89) and oldest-old (ages 90+) adults. But it remains unclear whether these age effects are magnified in advanced age groups, which may reflect disease-related pathology. Here, we tested whether age-related differences in white matter microstructure followed linear or nonlinear patterns across the entire older adult lifespan (65-98 years), these patterns were influenced by oldest-old adults at increased risk of dementia (cognitive impairment no dementia, CIND), and they explained age effects on episodic memory. Results revealed nonlinear microstructure declines across fiber classes (medial temporal, callosal, association, projection and/or thalamic) that were largest for medial temporal fibers. These patterns remained after excluding oldest-old participants with CIND, indicating that aging of white matter microstructure cannot solely be explained by pathology associated with early cognitive impairment. Moreover, finding that the effect of age on episodic memory was mediated by medial temporal fiber microstructure suggests it is essential for facilitating memory-related neural signals across the older adult lifespan.

Indexed as

LongevityMemory, EpisodicAgedAged, 80 and overAge FactorsAgingDiffusion Tensor ImagingFemaleHumansMaleNerve FibersRiskWhite MatterAgingCognitive statusDTIEpisodic memoryNonagenariansWhite matter

Identifiers

PMID34332220
PMCPMC10234268
OpenAlexW3164984727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.