Evidence map›Paper›PMID 34332160›Full record

ArticleBone2021

Differential relationships between parent-child DXA and pQCT bone measures: Results from the Southampton Women's Survey.

C R Holroyd, S Carter, S R Crozier, S D'Angelo, E M Curtis, R J Moon, J H Davies, K A Ward, E M Dennison, H M Inskip and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

C R HolroydMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Rheumatology Department, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
S CarterMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
S R CrozierMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
S D'AngeloMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
E M CurtisMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Rheumatology Department, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
R J MoonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
J H DaviesPaediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
K A WardMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
E M DennisonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
H M InskipMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
K M GodfreyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
C CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
N C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: nch@mrc.soton.ac.uk.
University Hospital Southampton NHS Foundation Trust · GBMRC Lifecourse Epidemiology Unit · GBUniversity of Southampton · GB

Funding

Interdisciplinary Research Network on Early Adversity & Later Life ReversibilityU24AG047867 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GODFREY, KEITH, MCEWEN, BRUCE S. · 2014 to 2018
$954k
Medical Research Council G0400491Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/4NIA NIH HHS U24 AG047867Versus Arthritis 17702Versus Arthritis 21231Wellcome Trust 201222/Z/16/Z
6 · The paper itself

Abstract

aimTo investigate the associations between indices of bone health in childhood and corresponding parental measures.

methodsThe Southampton Women's Survey characterised 12,583 non-pregnant women aged 20-34 years; 3158 subsequently had singleton live births. In a subset, dual-energy X-ray absorptiometry (DXA) measurements of bone area (BA), bone mineral content (BMC) and areal bone mineral density (aBMD) lumbar spine and total hip were obtained in the parent/offspring (aged 8-9 years) trios. Another subset of children (aged 6-7 years), and their parents, had peripheral quantitative computed tomography (pQCT; 4% and 38% tibia) measures. Using multivariable linear regression we examined relationships between mother/father and offspring, adjusting for parental age, habitual walking speed and education; offspring age and sex; and the corresponding bone measure in the other parent (β-coefficients (95%CI) unit/unit for each bone measure).

resultsData were available for 260 trios with DXA and 99 with pQCT. There were positive associations for BA, BMC and aBMD between either parent and offspring. Mother-child associations were of greater magnitude than father-child; for example, mother-child aBMD (β = 0.26 g·cm

conclusionsWhilst offspring bone measures are independently associated with those of either parent, the magnitude of the association is often greater for maternal than paternal relationships. These findings are consistent with an in utero influence on offspring growth but might also reflect genetic and/or epigenetic parent of origin effects. SUMMARY: In an established parent-offspring cohort, associations between parent and offspring bone indices were generally greater in magnitude for mother-offspring than father-offspring relationships.

Indexed as

Bone and BonesBone DensityAbsorptiometry, PhotonFemaleHumansLumbar VertebraeParent-Child RelationsBMDDevelopmental originsEpidemiologyMother-offspringOsteoporosis

Identifiers

PMID34332160
PMCPMC7611825
OpenAlexW3183719704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.