Evidence map›Paper›PMID 34332048›Full record

ArticleOsteoarthritis and cartilage2021

Clinical value of weight-bearing CT and radiographs for detecting patellofemoral cartilage visualized by MRI in the MOST study.

N A Segal, M T Murphy, B M Everist, K D Brown, J He, J A Lynch, M C Nevitt

Abstract read
In one paragraph

Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Article
  13. Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

N A SegalDepartment of Rehabilitation Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mailstop 1046, Kansas City, KS, 66160, USA. Electronic address: segal-research@kumc.edu.
M T MurphyDepartment of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: mmurphy11@kumc.edu.
B M EveristDepartment of Radiology, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: beverist@kumc.edu.
K D BrownDepartment of Radiology, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: kbrown4@kumc.edu.
J HeDepartment of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: jhe@kumc.edu.
J A LynchDepartment of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA, USA. Electronic address: jlynch@psg.ucsf.edu.
M C NevittDepartment of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA, USA. Electronic address: Michael.Nevitt@ucsf.edu.

Funding

Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Accelerating Osteoarthritis Clinical Trials Through Responsive Low-Dose Standing CT ImagingR01AR071648 · NIAMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SEGAL, NEIL A · 2018 to 2020
$607k
NIAMS NIH HHS R01 AR071648NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG019069
6 · The paper itself

Abstract

objectiveThe patellofemoral joint is frequently affected by osteoarthritis (PFOA) and is incompletely imaged on radiographs (XR). Weight-Bearing CT (WBCT) could offer advantages for visualization. This study determined the sensitivity, specificity, and accuracy of axial WBCT and lateral XR for detection of PFOA features in comparison with cartilage damage on MRI.

designA convenience sample of 60 right knees from the MOST cohort were analyzed. WBCT and XR were read for OARSI JSN score and MRI for MOAKS cartilage score by two experienced musculoskeletal radiologists blinded to participant. Using MOAKS scoring on MRI (referent standard), the sensitivity, specificity and accuracy of patellofemoral OARSI JSN scores based on WBCT and XR were compared.

resultsThe mean ± SD age and BMI for the participants included (66.7% women) were 67.6 ± 9.8 years and 30.0 ± 5.3 kg/m

conclusionWBCT demonstrates significantly greater sensitivity and accuracy than radiographs for identification of PFOA. Given the same Relative Radiation Level as XR and improved visualization, WBCT holds promise to improve understanding of the weight-bearing patellofemoral joint.

Indexed as

Weight-BearingAgedCartilage, ArticularCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMalePatellofemoral JointRadiographySampling StudiesTomography, X-Ray ComputedAccuracyPatellofemoral osteoarthritisRadiographsSensitivityWeight-bearing CT

Identifiers

PMID34332048
PMCPMC8542599

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.