Evidence map›Paper›PMID 34332029›Full record

ReviewNeuroscience letters2021

Mini review: Biomaterials in repair and regeneration of nerve in a volumetric muscle loss.

Neelam Ahuja, Kamal Awad, Sara Peper, Marco Brotto, Venu Varanasi

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Neelam AhujaBone Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, United States.
Kamal AwadBone Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, United States; Materials Science and Engineering Department, College of Engineering, University of Texas at Arlington, Arlington, TX 76019, United States; Department of Ceramics and Building Materials, National Research Center, Dokki, Cairo 12622, Egypt.
Sara PeperBone Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, United States; Bioengineering Department, College of Engineering, University of Texas at Arlington, Arlington, TX 76019, United States.
Marco BrottoBone Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, United States.
Venu VaranasiBone Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, United States; Materials Science and Engineering Department, College of Engineering, University of Texas at Arlington, Arlington, TX 76019, United States. Electronic address: venu.varanasi@uta.edu.
The University of Texas at Arlington · US

Funding

An Inverted Nikon A1R Laser Scanning Confocal MicroscopeS10OD025230 · OD · UNIVERSITY OF TEXAS ARLINGTON · PI PAN, ZUI · 2019 to 2019
$449k
Printing and Regenerating Fractured Bone Using Antioxidant MaterialsR56DE027964 · NIDCR · UNIVERSITY OF TEXAS ARLINGTON · PI VARANASI, VENU GOPAL · 2019 to 2019
$428k
Silicon, a Novel Antioxidant Role in Bone HealingR03DE023872 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI VARANASI, VENU GOPAL · 2014 to 2015
$229k
NIDCR NIH HHS R03 DE023872NIDCR NIH HHS R56 DE027964NIH HHS S10 OD025230
6 · The paper itself

Abstract

Volumetric muscle loss (VML) following a severe trauma or injury is beyond the intrinsic regenerative capacity of muscle tissues, and hence interventional therapy is required. Extensive muscle loss concomitant with damage to neuromuscular components overwhelms the muscles' remarkable regenerative capacity. The loss of nervous and vascular tissue leads to further damage and atrophy, so a combined treatment for neuromuscular junction (NMJ) along with the volumetric muscle regeneration is important. There have been immense advances in the field of tissue engineering for skeletal muscle tissue and peripheral nerve regeneration, but very few address the interdependence of the tissues and the need for combined therapies to repair and regenerate fully functional muscle tissue. This review addresses the problem and presents an overview of the biomaterials that have been studied for tissue engineering of neuromuscular tissues associated with skeletal muscles.

Indexed as

Biocompatible MaterialsAnimalsHumansMuscle, SkeletalNerve RegenerationNeuromuscular JunctionTissue EngineeringBiocompatible MaterialsMuscle regenerationNerve regenerationNeuromuscular junctionTissue engineering

Identifiers

PMID34332029
PMCPMC8529875
OpenAlexW3186645048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.