Evidence map›Paper›PMID 34332027›Full record

ArticleNeuroscience letters2021

Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption.

Oak Z Chi, Antonio Chiricolo, Xia Liu, Nikhil Patel, Estela Jacinto, Harvey R Weiss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Oak Z ChiDepartment of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA. Electronic address: chi@rwjms.rutgers.edu.
Antonio ChiricoloDepartment of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA.
Xia LiuDepartment of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA.
Nikhil PatelDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
Estela JacintoDepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
Harvey R WeissDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · USJohnson University · US

Funding

The Regulation of Cell Metabolism and Proliferation by mTOR complex 2R01GM079176 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI JACINTO, ESTELA · 2008 to 2017
$2.8M
NIGMS NIH HHS R01 GM079176
6 · The paper itself

Abstract

Blood-brain barrier (BBB) disruption is one of the most important pathological changes following cerebral ischemia-reperfusion. We tested whether inhibition of the serum and glucocorticoid regulated kinase 1 (SGK1) would decrease BBB disruption and contribute to decreasing infarct size in the first few hours of cerebral ischemia-reperfusion within the thrombolysis therapy time window. After transient middle cerebral artery occlusion (MCAO), an SGK1 inhibitor GSK650394, or vehicle was administered into the lateral ventricle of rats. After one hour of MCAO and two hours of reperfusion, we determined BBB disruption using the transfer coefficient (K

Indexed as

AnimalsBenzoatesBlood-Brain BarrierBridged Bicyclo Compounds, HeterocyclicCerebral InfarctionImmediate-Early ProteinsMaleNeuroprotective AgentsProtein Serine-Threonine KinasesRatsRats, Inbred F344Reperfusion InjurySerum-Glucocorticoid Regulated Kinases2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acidBenzoatesBridged Bicyclo Compounds, HeterocyclicImmediate-Early ProteinsNeuroprotective AgentsProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesBlood-brain barrierBrain protectionCerebral ischemia-reperfusionGSK650394SGK1

Identifiers

PMID34332027
PMCPMC8434992
OpenAlexW3186029795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.