Evidence map›Paper›PMID 34331972›Full record

ArticleJournal of molecular and cellular cardiology2021

Reperfusion mediates heme impairment with increased protein cysteine sulfonation of mitochondrial complex III in the post-ischemic heart.

Chwen-Lih Chen, Patrick T Kang, Liwen Zhang, Kunhong Xiao, Jay L Zweier, William M Chilian, Yeong-Renn Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Mitochondrial redox regulation and myocardial ischemia-reperfusion injury.American journal of physiology. Cell physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chwen-Lih ChenDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, United States of America.
Patrick T KangDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, United States of America.
Liwen ZhangCampus Chemical Instrument Center, Proteomics and Mass Spectrometry Facility, The Ohio State University, Columbus, OH 43210, United States of America.
Kunhong XiaoDepartment of Pharmacology and Chemical Biology and Biomedical Mass Spectrometry Center, University of Pittsburgh, PA 15261, United States of America.
Jay L ZweierDavis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States of America.
William M ChilianDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, United States of America.
Yeong-Renn ChenDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, United States of America. Electronic address: ychen1@neomed.edu.
Northeast Ohio Medical University · USLung Institute · USThe Ohio State University · USUniversity of Pittsburgh · US

Funding

Myocardial Injury Mitochondria/ Oxygen Free Radical(s)R01HL083237 · NHLBI · OHIO STATE UNIVERSITY · PI CHEN, YEONG-RENN · 2006 to 2017
$3.8M
NHLBI NIH HHS R01 HL083237
6 · The paper itself

Abstract

A serious consequence of myocardial ischemia-reperfusion injury (I/R) is oxidative damage, which causes mitochondrial dysfunction. The cascading ROS can propagate and potentially induce heme bleaching and protein cysteine sulfonation (PrSO

Indexed as

AnimalsBenzene DerivativesCattleCysteineCytochromes c1Electron Transport Complex IIIHemeMaleMice, TransgenicMitochondria, HeartMyocardial IschemiaMyocardial Reperfusion InjuryPeroxynitrous AcidRatsRats, Sprague-DawleySuperoxide DismutaseBenzene Derivativescumene hydroperoxideCysteineCytochromes c1Electron Transport Complex IIIHemePeroxynitrous AcidRieske iron-sulfur proteinSuperoxide DismutaseSuperoxide Dismutase 2Complex IIICysteine sulfonationHeme damageMyocardial ischemia and reperfusionOxidative stressProtein structure

Identifiers

PMID34331972
PMCPMC8629835
OpenAlexW3183650751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.