Evidence map›Paper›PMID 34331768›Full record

ArticleClinical and experimental immunology2021

Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma-tocotrienol supplementation.

Shonia Subramaniam, Jeya Seela Anandha Rao, Premdass Ramdas, Mei Han Ng, Methil Kannan Kutty, Kanga Rani Selvaduray, Ammu Kutty Radhakrishnan

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shonia SubramaniamSchool of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia.
Jeya Seela Anandha RaoPathology Division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Premdass RamdasDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia.ORCID 0000-0002-8521-7668
Mei Han NgEngineering and Processing, Malaysian Palm Oil Board, Kajang, Malaysia.ORCID 0000-0002-6165-5524
Methil Kannan KuttyFaculty of Medicine, Lincoln University, Petaling Jaya, Malaysia.
Kanga Rani SelvadurayProduct Development and Advisory Services, Malaysian Palm Oil Board, Kajang, Malaysia.ORCID 0000-0003-1832-3118
Ammu Kutty RadhakrishnanPathology Division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.ORCID 0000-0003-2638-907X
Malaysian Palm Oil Board · MYIMU University · MYLincoln University College · MYMonash University Malaysia · MY

Funding

International Medical University (IMU)Malaysian Palm Oil BoardMinistry of Higher Education, Malaysia FRGS/1/2013/SG05/IMU/01/1
6 · The paper itself

Abstract

Gamma-tocotrienol (γT3) is an analogue of vitamin E with beneficial effects on the immune system, including immune-modulatory properties. This study reports the immune-modulatory effects of daily supplementation of γT3 on host T helper (Th) and T regulatory cell (T

Indexed as

Dietary SupplementsAnimalsCell Line, TumorCytokinesFemalegamma-TocopherolKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMammary Neoplasms, AnimalMiceMice, Inbred BALB CNeoplasm ProteinsT-Lymphocytes, RegulatoryTumor MicroenvironmentCytokinesgamma-TocopherolNeoplasm Proteinsadaptive immunitybreast cancergamma-tocotrienolmouse modelT lymphocyte

Identifiers

PMID34331768
PMCPMC8506134
OpenAlexW3165667934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.