Evidence map›Paper›PMID 34331702›Full record

ArticleJournal of the American Geriatrics Society2021

Identifying high-risk surgical patients: A study of older adults whose code status changed to Do-Not-Resuscitate.

Hadiza S Kazaure, Tracy Truong, Maragatha Kuchibhatla, Sandhya Lagoo-Deenadayalan, Sherry M Wren, Kimberly S Johnson

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Hadiza S KazaureDivision of Surgical Oncology, Department of Surgery, Duke University, Durham, North Carolina, USA.
Tracy TruongDepartment of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
Maragatha KuchibhatlaDepartment of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
Sandhya Lagoo-DeenadayalanDivision of Surgical Oncology, Department of Surgery, Duke University, Durham, North Carolina, USA.
Sherry M WrenDepartment of General Surgery, Stanford University School of Medicine, Stanford, California, USA.
Kimberly S JohnsonDepartment of Surgery, Durham VA Health Care System, Durham, North Carolina, USA.

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
NCATS NIH HHS UL1 TR002553
6 · The paper itself

Abstract

backgroundThere is a paucity of data on older adults (age ≥65 years) undergoing surgery who had an inpatient do-not-resuscitate (DNR) order, and the association between timing of DNR order and outcomes.

methodsThis was a retrospective analysis of 1976 older adults in the American College of Surgeons National Surgical Quality Improvement Program geriatric-specific database (2014-2018). Patients were stratified by institution of a DNR order during their surgical admission ("new-DNR" vs. "no-DNR"), and matched by age (±3 years), frailty score (range: 0-1), and procedure. The main outcome of interest was occurrence of death or hospice transition (DoH) ≤30 postoperative days; this was analyzed using bivariate and multivariable methods.

resultsOne in 36 older adults had a new-DNR order. After matching, there were 988 new-DNR and 988 no-DNR patients. Median age and frailty score were 82 years and 0.2, respectively. Most underwent orthopedic (47.6%), general (37.6%), and vascular procedures (8.4%). Overall DoH rate ≤30 days was 44.4% for new-DNR versus 4.0% for no-DNR patients (p < 0.001). DoH rate for patients who had DNR orders placed in the preoperative, day of surgery, and postoperative setting was 16.7%, 23.3%, and 64.6%, respectively (p < 0.001). In multivariable analysis, compared to no-DNR patients, those with a new-DNR order had a 28-fold higher adjusted odds of DoH (odds ratio [OR] 28.1, 95% confidence interval: 13.0-60.1, p < 0.001); however, odds were 10-fold lower if the DNR order was placed preoperatively (OR: 5.8, p = 0.003) versus postoperatively (OR: 52.9, p < 0.001). Traditional markers of poor postoperative outcomes such as American Society of Anesthesiologists class and emergency surgery were not independently associated with DoH.

conclusionsAn inpatient DNR order was associated with risk of DoH independent of traditional markers of poor surgical outcomes. Further research is needed to understand factors leading to a DNR order that may aid early recognition of high-risk older adults undergoing surgery.

Indexed as

Resuscitation OrdersAgedAged, 80 and overDatabases, FactualFemaleHospice CareHospital MortalityHumansInpatientsMaleOdds RatioPerioperative CareRetrospective StudiesRisk AssessmentSurgical Procedures, OperativeTime Factorsdo-not-resuscitatefrailtygeriatricshospiceoutcomessurgery

Identifiers

PMID34331702
PMCPMC8909704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.