ArticleEndocrine2021
Association between dietary onion intake and subclinical hypothyroidism in adults: a population-based study from an iodine-replete area.
Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder.BMC psychiatry · 2025Article
- Interaction Between Dietary Selenium and Zinc Intakes on Hypothyroidism.Biological trace element research · 2023Article
- Association between thyroid dysfunction, metabolic disturbances, and clinical symptoms in first-episode, untreated Chinese patients with major depressive disorder: Undirected and Bayesian network analyses.Frontiers in endocrinology · 2023Article
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe protective effect of onion against thyroid hypofunction has been reported in animal studies. However, in humans, the association between onion consumption and subclinical hypothyroidism (SCH) are unclear. The study sought to explore the association between habitual onion intake and SCH among adult population from an iodine-replete area.
methodsA cross-sectional study (6515 men and 5290 women) was performed in Tianjin, China. Frequency of onion consumption was assessed using a valid self-administered food frequency questionnaire. Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were determined by chemiluminescence immunoassay. SCH was diagnosed with TSH > 4.78 mIU/L. Multiple logistic regression was used to evaluate the association of onion intake with SCH.
resultsThe prevalence of SCH was 2.56% in men and 7.18% in women, respectively. In women, the fully adjusted odds ratios [95% confidence interval (CI)] of having SCH across increasing frequency of onion intake were 1.00 (reference) for <1 time/week, 0.99 (0.73, 1.34) for 1-3 times/week, 0.74 (0.53, 1.03) for 4-6 times/week, and 0.67 (0.47, 0.97) for ≥7 times/week (P for trend <0.01). However, we observed no significant association between onion intake and SCH in men. Stratified analyses suggested a potential effect modification by age: the odds ratios (95% CI) across extreme quartiles was 0.37 (0.17, 0.80) in <40 women and 1.11 (0.51, 2.47) in >60 women.
conclusionsFrequent consumption of onion is inversely associated with SCH in adult women from an iodine-replete area. Further studies are needed to explore the casual relationship. TRIAL REGISTRATION WEBSITE: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000031137.
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