Evidence map›Paper›PMID 34331570›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Novel RGAG1-BCOR gene fusion revealed in a somatic soft tissue sarcoma with a long follow-up.

Mauro Vasella, Ulrich Wagner, Christine Fritz, Kati Seidl, Luca Giudici, Gerhard Ulrich Exner, Holger Moch, Peter Johannes Wild, Beata Bode-Lesniewska

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PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Mauro VasellaDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. mauro.vasella@usz.ch.ORCID http://orcid.org/0000-0003-0973-6084
Ulrich WagnerInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Christine FritzInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Kati SeidlInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Luca GiudiciInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Gerhard Ulrich ExnerOrthopaedie Zentrum Zuerich, Ozz, Zurich, Switzerland.
Holger MochInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Peter Johannes WildSenckenberg Institute of Pathology, Goethe University Frankfurt, Frankfurt, Germany.
Beata Bode-LesniewskaPathology Institute Enge and University of Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHGoethe University Frankfurt · DEImmunologie-Zentrum Zürich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BCOR-rearranged sarcomas are rare and belong to the Ewing-like sarcomas (ELS). Their morphology and histopathological features make the diagnosis challenging. We present a case, initially diagnosed as an unusual extraskeletal myxoid chondrosarcoma (EMC). A 54-year-old male patient developed an asymptomatic swelling of the lower leg. Imaging showed a 9.5-cm large intramuscular soft tissue mass. Due to its morphological and immunohistochemical profile on biopsy, it was initially diagnosed as an EMC. The patient was treated by complete resection and adjuvant radiotherapy and remained free of tumor at 7 years follow-up. Using next-generation sequencing (NGS), we retrospectively identified RGAG1-BCOR gene fusion (confirmed by RT-PCR), which has not been described in somatic soft tissue tumors so far. This finding broadens the spectrum of partner genes in the BCOR-rearranged sarcomas in a tumor with a well-documented, long clinical follow-up.

Indexed as

Bone NeoplasmsSarcomaSoft Tissue NeoplasmsBiomarkers, TumorChondrosarcomaFollow-Up StudiesGene FusionHumansMaleMiddle AgedNeoplasms, Connective and Soft TissueOncogene Proteins, FusionProto-Oncogene ProteinsRepressor ProteinsRetrospective StudiesBCOR protein, humanBiomarkers, TumorOncogene Proteins, FusionProto-Oncogene ProteinsRepressor ProteinsBCOREwing-likeNext-generation sequencingRGAG1Sarcoma

Identifiers

PMID34331570
PMCPMC9033707
OpenAlexW3184923503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.