ArticleEnvironmental and molecular mutagenesis2021
Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust.
Article in Environmental and molecular mutagenesis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Unveiling Urinary Mutagenicity by the Ames Test for Occupational Risk Assessment: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Effects of urban-induced mutations on ecology, evolution and health.Nature ecology & evolution · 2024Review
- Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number.Carcinogenesis · 2023Article
- Household air pollution and epigenetic aging in Xuanwei, China.Environment international · 2023Article
- Urinary Amino-PAHs in relation to diesel engine emissions and urinary mutagenicity.International journal of hygiene and environmental health · 2023Article
- Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA.Occupational and environmental medicine · 2023Article
- Occupational determinants of health.International public health journalArticle
- Urinary mutagenicity and bladder cancer risk in northern New England.Environmental and molecular mutagenesisArticle
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 4 countries.
Funding
Abstract
Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/carcinogenic agents and is linked to tumor development. Coal combustion emissions (CCE) and diesel engine exhaust (DEE) are associated with cancers of the lung and other sites, but their influence on urinary mutagenicity is unclear. We investigated associations between exposure to CCE or DEE and urinary mutagenicity. In two separate cross-sectional studies of nonsmokers, organic extracts of urine were evaluated for mutagenicity levels using strain YG1041 in the Salmonella (Ames) mutagenicity assay. First, we compared levels among 10 female bituminous (smoky) coal users from Laibin, Xuanwei, China, and 10 female anthracite (smokeless) coal users. We estimated exposure-response relationships using indoor air concentrations of two carcinogens in CCE relevant to lung cancer, 5-methylchrysene (5MC), and benzo[a]pyrene (B[a]P). Second, we compared levels among 20 highly exposed male diesel factory workers and 15 unexposed male controls; we evaluated exposure-response relationships using elemental carbon (EC) as a DEE-surrogate. Age-adjusted linear regression was used to estimate associations. Laibin smoky coal users had significantly higher average urinary mutagenicity levels compared to smokeless coal users (28.4 ± 14.0 SD vs. 0.9 ± 2.8 SD rev/ml-eq, p = 2 × 10
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