ArticleActa paediatrica (Oslo, Norway : 1992)2021
Multi-inflammatory syndrome and Kawasaki disease in children during the COVID-19 pandemic: A nationwide register-based study and time series analysis.
Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Clinical characteristics and trend changes of Kawasaki disease in children because of the Omicron pandemic.Italian journal of pediatrics · 2025Article
- Coronary artery lesions in children with Kawasaki disease: status quo and nursing care.Frontiers in cardiovascular medicine · 2024Article
- Analysis of Plasmablasts From Children With Kawasaki Disease Reveals Evidence of a Convergent Antibody Response to a Specific Protein Epitope.The Journal of infectious diseases · 2023Article
- Epidemiological and Clinical Features of Kawasaki Disease During the COVID-19 Pandemic in the United States.JAMA network open · 2022Article
- Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study.BMJ (Clinical research ed.) · 2022Article
- Number of Kawasaki Disease Admissions Is Associated with Number of Domestic COVID-19 and Severe Enterovirus Case Numbers in Taiwan.Children (Basel, Switzerland) · 2022Article
- The SARS-CoV-2 Pandemic Impacts the Management of Swiss Pediatric Intensive Care Units.Frontiers in pediatrics · 2022Article
- An Unintended Consequence of Pandemic Control Measures: Fewer Cases of Kawasaki Disease.The Journal of pediatrics · 2021Article
- Multi-inflammatory syndrome and Kawasaki disease in children during the COVID-19 pandemic: A nationwide register-based study and time series analysis.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure.mSystems · 2021Article
- Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe investigated whether the ongoing COVID-19 pandemic was associated with the occurrence of Kawasaki disease or with multi-inflammatory syndrome in children (MIS-C).
methodsThis national Finnish register-based study was based on laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, MIS-C and Kawasaki disease cases. We performed a time series analysis on the occurrence of Kawasaki disease in 2016-2020.
resultsIn 2020, there were 5170 laboratory-confirmed COVID-19 cases in children under 18 years of age and five fulfilled the MIS-C case definition. The occurrence of MIS-C was 0.97 per 1000 (95% confidence interval: 0.31-2.26) laboratory-confirmed SARS-CoV-2 infections in children. Our time series analysis showed that Kawasaki disease cases decreased during the COVID-19 pandemic. The seasonally adjusted incidence rate ratio was 0.49 (95% confidence interval: 0.32-0.74) when it was compared to pre-pandemic levels. This coincided with a reduced occurrence of respiratory infections, due to social distancing in the population.
conclusionThis nationwide register-based study found that MIS-C was a rare complication of the SARS-CoV-2 infection. The occurrence of Kawasaki disease and respiratory infections decreased during the pandemic. This suggests that transmissible microbes may play an important role in Kawasaki disease and social distancing may have a protective effect.
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