Evidence map›Paper›PMID 34331176›Full record

ArticleBiological trace element research2022

Antioxidant Activities and Selenogene Transcription in the European Sea Bass (Dicentrarchus labrax) Liver Depend, in a Non-linear Manner, on the Se/Hg Molar Ratio of the Feeds.

Marinelle Espino, Harkaitz Eguiraun, Oihane Diaz de Cerio, José Antonio Carrero, Nestor Etxebarria, Iciar Martinez

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Marinelle EspinoResearch Center for Experimental Marine Biology and Biotechnology - Plentziako Itsas Estazioa (PiE), University of the Basque Country (UPV/EHU), Areatza 47, 48620, Plentzia, Bizkaia, Spain. mespino@seafdec.org.ph.ORCID http://orcid.org/0000-0001-8519-8201
Harkaitz EguiraunResearch Center for Experimental Marine Biology and Biotechnology - Plentziako Itsas Estazioa (PiE), University of the Basque Country (UPV/EHU), Areatza 47, 48620, Plentzia, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-4014-6376
Oihane Diaz de CerioResearch Center for Experimental Marine Biology and Biotechnology - Plentziako Itsas Estazioa (PiE), University of the Basque Country (UPV/EHU), Areatza 47, 48620, Plentzia, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-5605-8434
José Antonio CarreroDepartment of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-5823-7743
Nestor EtxebarriaResearch Center for Experimental Marine Biology and Biotechnology - Plentziako Itsas Estazioa (PiE), University of the Basque Country (UPV/EHU), Areatza 47, 48620, Plentzia, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-2942-9463
Iciar MartinezResearch Center for Experimental Marine Biology and Biotechnology - Plentziako Itsas Estazioa (PiE), University of the Basque Country (UPV/EHU), Areatza 47, 48620, Plentzia, Bizkaia, Spain. iciar.martinez@ehu.eus.ORCID http://orcid.org/0000-0002-2317-8886
University of the Basque Country · ESIkerbasque · ESSoutheast Asian Fisheries Development Center · PH

Funding

Euskampus Fundazioa-Campus of International Excellence 307615SAA2Eusko Jaurlaritza KK-2016/00057Spanish MINECO CTM2012-40203-C02-01Spanish MINECO RTC-2014-2837-2
6 · The paper itself

Abstract

Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively affected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the transcription of txn1, gpx1, and txnrd2. Feeding 6.7 mg Hg/kg for 53 days downregulated the genes of the thioredoxin system (txn1, txnrd3, and txnrd2) but upregulated gpx1, confirming the previously proposed complementarity among the antioxidant systems. Substitution of 20% of the feed by thawed white fish (hake) slightly counteracted the negative effects of Hg. The effects were not statistically significant and were dependent, in a non-linear manner, on the Se/Hg molar ratio of the feed but not on its Hg concentration. These results stress the need to consider the Se/Hg molar ratio of the feed/food when evaluating the toxicity of Hg.

Indexed as

BassMercurySeleniumAnimalsAntioxidantsLiverThioredoxinsAntioxidantsMercurySeleniumThioredoxinsDicentrarchus labraxFishGlutathione peroxidaseMercury (Hg)SeafoodSelenium (Se)Selenogene transcriptionThioredoxin reductase

Identifiers

PMID34331176
PMCPMC9023391
OpenAlexW3184392139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.