Evidence map›Paper›PMID 34331101›Full record

ArticleArchives of microbiology2021

The sufficient vitamin D and albumin level have a protective effect on COVID-19 infection.

Somaieh Matin, Nasrin Fouladi, Yasamin Pahlevan, Vahid Asghariazar, Soheila Molaei, Hamid Afzoun Khiavi, Mohamad Negaresh, Elham Safarzadeh

Open access · bronzeAbstract read
In one paragraph

Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Somaieh MatinDepartment of Internal Medicine, Imam khomeini hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Nasrin FouladiSchool of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.
Yasamin PahlevanDeputy of Research and Technology, Ardabil University of Medical Sciences, Ardabil, Iran.
Vahid AsghariazarDeputy of Research and Technology, Ardabil University of Medical Sciences, Ardabil, Iran.
Soheila MolaeiDeputy of Research and Technology, Ardabil University of Medical Sciences, Ardabil, Iran.
Hamid Afzoun KhiaviImmunology Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Mohamad NegareshStudents Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Elham SafarzadehDepartment of Microbiology, Parasitology, and Immunology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. E.safarzadeh@arums.ac.ir.ORCID http://orcid.org/0000-0001-6160-8923
Ardabil University of Medical Sciences · IRGuilan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is limited information regarding the protective factors of SARS-CoV-2 infection. This research is focused on analyzing the role of vitamin D and albumin in the severity, progression, or possible prevention of COVID-19 infection. In this case-control study, 191 patients and 203 healthy individuals were enrolled. Blood samples were taken to test the albumin and vitamin D levels of both groups. Our results show a direct association of vitamin D deficiency with the infection of COVID-19 and severity. According to our findings, 84.4% of patients with COVID-19 in this study had vitamin D deficiency. Moreover, the average level of albumin was significantly decreased in those infected patients who had respiratory symptoms. In the present study, a considerable negative correlation was established between the levels of vitamin D and the severity of COVID-19 infection. This reflects on the immunomodulatory and inhibitory nature of vitamin D to the viral replication.

Indexed as

COVID-19Vitamin DAlbuminsCase-Control StudiesHumansSARS-CoV-2AlbuminsVitamin DAlbuminCoronavirusCOVID-19Vitamin D

Identifiers

PMID34331101
PMCPMC8324433
OpenAlexW3183622459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.