ArticlePediatric cardiology2022
Echocardiographic Reference Ranges of Non-invasive Myocardial Work Indices in Children.
Article in Pediatric cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Survival and Clinical Progression in Barth Syndrome: Insights From the Barth Syndrome Foundation's Database of 502 Affected Individuals.Journal of inherited metabolic disease · 2026Article
- Myocardial work efficiency in children with Wolff-Parkinson-White preexcitation before and after accessory pathway ablation.Frontiers in cardiovascular medicine · 2026Article
- Shock index, modified shock index, and age-adjusted shock index for the prediction of impaired myocardial work in patients with ST-segment elevation myocardial infarction.Quantitative imaging in medicine and surgery · 2025Article
- Comparative Reproducibility of Myocardial Work and Left Ventricular Ejection Fraction in Patients After an Acute Coronary Syndrome.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Pediatric Echocardiographic Nomograms: Twenty Years of Advances-Do We Now Have a Complete and Reliable Tool, or Are Gaps Still Present? An Up-to-Date Review.Journal of clinical medicine · 2025Review
- Towards non-invasive assessment of myocardial work using myocardial stiffness and strain: a human pilot study.European heart journal. Cardiovascular Imaging · 2025Article
- Normal Values for Echocardiographic Myocardial Work in a Large Pediatric Population.Diagnostics (Basel, Switzerland) · 2024Article
- Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short-term postoperative effect.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Pressure-Strain Loops, a Novel Non-invasive Approach for Assessment of Children with Cardiomyopathy.Pediatric cardiology · 2022Article
- Echocardiographic Reference Ranges of Non-Invasive Myocardial Work Indices in Newborns.Circulation reports · 2022Article
- Myocardial work and takotsubo syndrome: stress affects work.The international journal of cardiovascular imaging · 2022Article
- Decreased Global Myocardial Work Efficiency Correlates with Coronary Vasculopathy in Pediatric Heart Transplant Patients.Pediatric cardiology · 2022Article
- Reference Values of Noninvasive Myocardial Work Indices Measured by Echocardiography in Healthy Children.Frontiers in pediatrics · 2022Article
- Normal ranges of non-invasive left ventricular myocardial work indices in healthy young people.Frontiers in pediatrics · 2022Article
- Echocardiographic myocardial work in pre-adolescent male basketball players: a comparison with cardiopulmonary exercise test-derived aerobic capacity.Frontiers in physiology · 2022Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global myocardial work (GMW) is an emerging method to characterize left ventricle (LV) function with potential advantages over both ejection fraction and global longitudinal strain (GLS). We aimed to determine the feasibility and reproducibility for echocardiographic-derived GMW in a healthy pediatric population; establish normal reference values; and investigate the influence of age, gender, and other clinical factor on normal reference ranges. We prospectively enrolled 212 individuals (median age of 9 years; interquartile range, 6 to 12 years, 112 female). Global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were measured from LV pressure-strain loops. Quantification of GMW was performed using a GE Vivid E95 system and available software package (Echopac V.203, GE). The mean LV EF was 64 ± 3% with GLS of -21.3 ± 1.5%. GWI was 1688 ± 219 mmHg% with mean GWE of 96.5 ± 1.4%. The GCW was 1959 ± 207 mmHg%, and the mean GWW of 61.1 ± 30.9 mmHg%. No significant difference was found in MW indices across age group and gender (p > 0.05 for all). There were significant correlations between both GWI and GCW with GLS and systolic blood pressure (p < 0.001), but not with GWE and GWW. Linear regression model revealed that GWI and GCW were more closely correlated with systolic blood pressure than GLS. LV MW indices had good intra-observer and inter-observer reproducibility. This study establishes both the feasibility and reference ranges for non-invasive echocardiographic indices of GMW in healthy children. Myocardial work appears to be a complementary modality to assess LV performance in children.
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