ArticleCerebral cortex (New York, N.Y. : 1991)2022
Directed Brain Connectivity Identifies Widespread Functional Network Abnormalities in Parkinson's Disease.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Large-scale functional overlap between dorsal and ventral object-responsive networks.Research square · 2026Article
- Pathological cortico-STN beta coupling in Parkinson's disease is confined to beta bursts.bioRxiv : the preprint server for biology · 2026Article
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Article
- Analyzing Information Exchange in Parkinson's Disease via Eigenvector Centrality: A Source-Level Magnetoencephalography Study.Journal of clinical medicine · 2025Article
- Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles.Translational psychiatry · 2025Article
- Artificial Intelligence and Neuroscience: Transformative Synergies in Brain Research and Clinical Applications.Journal of clinical medicine · 2025Review
- Blurred magnitude homology of functional connectome for ASD diagnosis.Frontiers in psychiatry · 2025Article
- Structural inequality and temporal brain dynamics across diverse samples.Clinical and translational medicine · 2024Article
- Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology.Alzheimer's research & therapy · 2023Article
- Sex differences in multilayer functional network topology over the course of aging in 37543 UK Biobank participants.Network neuroscience (Cambridge, Mass.) · 2023Article
- Directed Functional Brain Connectivity is Altered in Sub-threshold Amyloid-β Accumulation in Cognitively Normal Individuals.Neuroscience insights · 2023Article
- Treadmill training in Parkinson's disease is underpinned by the interregional connectivity in cortical-subcortical network.NPJ Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by topological abnormalities in large-scale functional brain networks, which are commonly analyzed using undirected correlations in the activation signals between brain regions. This approach assumes simultaneous activation of brain regions, despite previous evidence showing that brain activation entails causality, with signals being typically generated in one region and then propagated to other ones. To address this limitation, here, we developed a new method to assess whole-brain directed functional connectivity in participants with PD and healthy controls using antisymmetric delayed correlations, which capture better this underlying causality. Our results show that whole-brain directed connectivity, computed on functional magnetic resonance imaging data, identifies widespread differences in the functional networks of PD participants compared with controls, in contrast to undirected methods. These differences are characterized by increased global efficiency, clustering, and transitivity combined with lower modularity. Moreover, directed connectivity patterns in the precuneus, thalamus, and cerebellum were associated with motor, executive, and memory deficits in PD participants. Altogether, these findings suggest that directional brain connectivity is more sensitive to functional network differences occurring in PD compared with standard methods, opening new opportunities for brain connectivity analysis and development of new markers to track PD progression.
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