ArticleHypertension research : official journal of the Japanese Society of Hypertension2021
Sleep and cardiovascular outcomes in relation to nocturnal hypertension: the J-HOP Nocturnal Blood Pressure Study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality.GeroScience · 2025Pooled it
- Sleep duration and risk of cardio-cerebrovascular disease: A dose-response meta-analysis of cohort studies comprising 3.8 million participants.Frontiers in cardiovascular medicine · 2022Pooled it
- Pathophysiology, diagnosis and intervention strategies of nocturnal hypertension.Journal of human hypertension · 2026Review
- Sleep and Risk for Heart Disease and Stroke.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The Non-Dipping Blood Pressure Phenotype Is Independently Linked to Systemic Inflammation and Atherogenic Burden.Journal of clinical medicine · 2026Article
- Isolated nocturnal hypertension and its association with sleep duration and quality.Journal of human hypertension · 2026Article
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Prestroke sleep and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2025Review
- The influence of sleep duration on patients with coronary artery disease: a four-year observational study.Frontiers in endocrinology · 2025Observational
- Time in therapeutic range for out-of-office blood pressure in hypertensive disorders of pregnancy: A better risk assessment measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Sleep and hypertension - up to date 2024.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Short Sleep Duration and Hypertension: A Double Hit for the Brain.Journal of the American Heart Association · 2024Article
- Development of beat-by-beat blood pressure monitoring device and nocturnal sec-surge detection algorithm.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Home blood pressure-centered approach - from digital health to medical practice: HOPE Asia Network consensus statement 2023.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Digital hypertension towards to the anticipation medicine.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Prevalence and Characteristics of Isolated Nocturnal Hypertension and Masked Nocturnal Hypertension in a Tertiary Hospital in the City of Buenos Aires.Diagnostics (Basel, Switzerland) · 2023Article
- Masked Hypertension and Exaggerated Blood Pressure Response to Exercise: A Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Isolated nocturnal hypertension in relation to host and environmental factors and clock genes.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Sleep and nocturnal hypertension: Genes, environment, and individual profiles.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Long-term blood pressure lowering effect of renal denervation and its patient preference, salt intake, and stroke in Asia.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a lack of data on how nighttime blood pressure (BP) might modify the relationship between sleep duration and cardiovascular disease (CVD) risk. Self-reported sleep duration data were available for 2253/2562 patients from the J-HOP Nocturnal BP study; of these, 2236 had complete follow-up data (mean age 63.0 years, 83% using antihypertensive drugs). CVD outcomes included stroke, coronary artery disease (CAD), and atherosclerotic CVD (ASCVD [stroke + CAD]). Associations between sleep duration and nighttime home BP (measured using a validated, automatic, oscillometric device) were determined. During a mean follow-up of 7.1 ± 3.8 years, there were 133 ASCVD events (52 strokes and 81 CAD events). Short sleep duration (<6 versus ≥6 and <9 h/night) was significantly associated with the risk of ASCVD (hazard ratio [HR] 1.85, 95% confidence interval [CI] 1.07-3.22), especially stroke (HR 2.47, 95% CI 1.08-5.63). When nighttime systolic BP was <120 mmHg, those with a sleep duration <6 versus ≥6 and <9 h/night had a significantly higher risk of ASCVD and CAD events (HR [95% CI] 3.46 [1.52-7.92] and 3.24 [1.21-8.69], respectively). Even patients with "optimal" sleep duration (≥6 and <9 h/night) were at significantly higher risk of stroke when nighttime systolic BP was uncontrolled (HR [95% CI] 2.76 [1.26-6.04]). Adding sleep duration and nighttime BP to a base model with standard CVD risk factors significantly improved model performance for stroke (C-statistic 0.795, 95% CI 0.737-0.856; p = 0.038). These findings highlight the importance of both optimal sleep duration and control of nocturnal hypertension for reducing the risk of CVD, especially stroke. Clinical Trial registration: URL: http://www.umin.ac.jp/icdr/index.html . Unique identifier: UMIN000000894.
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