ArticleInternational journal of obesity (2005)2021
Distinct opposing associations of upper and lower body fat depots with metabolic and cardiovascular disease risk markers.
Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- From Modified Haller Index to a Novel Patented Anatomical Measurement Device: Engineering Development, Validation, and Clinical Applications of Non-Invasive Thoracic Morphometry.Bioengineering (Basel, Switzerland) · 2026Review
- Visceral-to-peripheral adiposity ratio in proneness to sarcopenic obesity: association with low muscle strength, but not low muscle mass, in young women of South Asian descent.International journal of obesity (2005) · 2026Article
- Association Between Trunk Fat Mass Index and Diabetes in a Multinational Population.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Validation of measurement of body composition by dual-energy X-ray absorptiometry and bioelectrical impedance analysis and body composition's profiling in Tibetan's adults.Public health nutrition · 2025Article
- Different obesity indicators and their correlation with hypertension, diabetes, and dyslipidemia in 35-74 years rural residents in Northwest China.Frontiers in endocrinology · 2025Article
- Impaired Mitochondrial Respiration in Upper Compared to Lower Body Differentiated Human Adipocytes and Adipose Tissue.The Journal of clinical endocrinology and metabolism · 2024Article
- The variations in health cost based on the traditional obesity parameters among patients with coronary artery diseases undergoing cardiac catheterization.BMC health services research · 2024Article
- Visceral-to-peripheral adiposity ratio: a critical determinant of sex and ethnic differences in cardiovascular risks among Asian Indians and African Creoles in Mauritius.International journal of obesity (2005) · 2024Article
- Associations between tinnitus and body composition: a cross-sectional study.Scientific reports · 2024Article
- Association of Aldosterone, Renin, and Aldosterone to Renin Ratio with Metabolic Profile in Primary Aldosteronism.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Article
- Body composition predicts hypertension using machine learning methods: a cohort study.Scientific reports · 2023Article
- It Is Not Just Fat: Dissecting the Heterogeneity of Adipose Tissue Function.Current diabetes reports · 2022Review
- Abdominal Adipose Tissue Associates With Adiponectin and TNFα in Middle-Aged Healthy Men.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTo examine the associations of total and regional adiposity with metabolic and cardiovascular disease (CVD) risk markers.
methodsThis cross-sectional study included 1080 (53.8% men, aged 39-44 years) individuals from South India. Anthropometry (height, weight, waist and hip circumference), body composition assessment using dual-energy X-ray absorptiometry (DXA), blood pressure (BP), and plasma glucose, insulin and lipids were measured. Regression analysis was used to examine associations of standardized fat measurements with type 2 diabetes (T2D), insulin resistance (IR), hypertension and hypertriglyceridemia and continuous measurements of BP, glucose, insulin, HOMA-IR and lipids. Contour plots were constructed to visualize the differential effect of upper and lower fat depots.
resultsDXA-measured fat depots were positively associated with metabolic and CVD risk markers. After adjusting for fat mass index, upper body fat remained positively, while lower body fat was negatively associated with risk markers. A one standard deviation (SD) increase in android fat showed higher odds ratios (ORs) for T2D (6.59; 95% CI 3.17, 13.70), IR (4.68; 95% CI 2.31, 9.50), hypertension (2.57; 95% CI 1.56, 4.25) and hypertriglyceridemia (6.39; 95% CI 3.46, 11.90) in men. A 1 SD increase in leg fat showed a protective effect with ORs for T2D (0.42; 95% CI 0.24, 0.74), IR (0.31; 95% CI 0.17, 0.57) and hypertriglyceridemia (0.61; 95% CI 0.38, 0.98). The magnitude of the effect was greater with DXA-measured fat compared with anthropometry.
conclusionAt any level of total body fat, upper and lower body fat depots demonstrate opposite risk associations with metabolic and CVD risk markers in Asian Indians.
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