Evidence map›Paper›PMID 34330990›Full record

ArticleScientific reports2021

Shape effect of cerium oxide nanoparticles on mild traumatic brain injury.

Dong Hyuk Youn, Ngoc Minh Tran, Bong Jun Kim, Youngmi Kim, Jin Pyeong Jeon, Hyojong Yoo

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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  14. Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury.Journal of controlled release : official journal of the Controlled Release Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dong Hyuk Youn *Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Republic of Korea.
Ngoc Minh Tran *Department of Materials Science and Chemical Engineering, Hanyang University, Ansan, Gyeonggi-do, 15588, Republic of Korea.
Bong Jun KimInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Republic of Korea.
Youngmi KimInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Republic of Korea.
Jin Pyeong JeonInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Republic of Korea. jjs6553@daum.net.
Hyojong YooDepartment of Materials Science and Chemical Engineering, Hanyang University, Ansan, Gyeonggi-do, 15588, Republic of Korea. hjhaha73@hanyang.ac.kr.
Hallym University · KRHanyang University · KRSNP Genetics (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The catalytic performance and therapeutic effect of nanoparticles varies with shape. Here, we investigated and compared the therapeutic outcomes of ceria nanospheres (Ceria NSs) and ceria nanorods (Ceria NRs) in an in vivo study of mild traumatic brain injury (mTBI). In vivo TBI was induced in a mouse model of open head injury using a stereotaxic impactor. Outcomes including cytoprotective effects, cognitive function, and cerebral edema were investigated after retro-orbital injection of 11.6 mM of ceria nanoparticles. Ceria nanoparticles significantly reduced fluoro-jade B (FJB)-positive cells and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells, and restored mRNA levels of superoxide dismutase 1 (SOD1) and SOD2. They also decreased the cyclooxygenase-2 (COX-2) expression compared with the untreated control group. Comparing the two nanomaterials, Ceria NRs showed less stable and high-energy (100) and (110) planes, which increased the number of active sites. The Ce

Indexed as

AnimalsCeriumCyclooxygenase 2DNA NucleotidylexotransferaseFemaleMaleMiceMice, Inbred C57BLNanoparticlesceric oxideCeriumCyclooxygenase 2DNA Nucleotidylexotransferase

Identifiers

PMID34330990
PMCPMC8324865
OpenAlexW3184268213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.