Evidence map›Paper›PMID 34330945›Full record

ArticleScientific reports2021

COVID-19 vaccines that reduce symptoms but do not block infection need higher coverage and faster rollout to achieve population impact.

David A Swan, Chloe Bracis, Holly Janes, Mia Moore, Laura Matrajt, Daniel B Reeves, Eileen Burns, Deborah Donnell, Myron S Cohen, Joshua T Schiffer and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 5 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 5 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Inferring the true number of SARS-CoV-2 infections in Japan.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022
    Pooled it
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  6. Trial
  7. Article
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  14. Review
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  16. A Scalar Approach to Vaccination Ethics.The journal of ethics · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

David A Swan *Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Chloe Bracis *Université Grenoble Alpes, TIMC-IMAG/BCM, 38000, Grenoble, France.
Holly JanesVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Mia MooreVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Laura MatrajtVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Daniel B ReevesVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Eileen BurnsIndependent Researcher, Seattle, WA, USA.
Deborah DonnellVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Myron S CohenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Joshua T Schiffer *Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA.
Dobromir Dimitrov *Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M2-C200, P.O. Box 19024, Seattle, WA, 98109-1024, USA. ddimitro@fredhutch.org.
Fred Hutch Cancer Center · USTranslational Innovation in Medicine and Complexity · FRUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USUniversity of Washington Applied Physics Laboratory · US

Funding

SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
Immunoprotective Properties of Tissue-resident Memory T Cells in Mice and Humans within Mucosal SitesR01AI121129 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LUND, JENNIFER M, PRLIC, MARTIN · 2016 to 2022
$5.0M
CDC HHS NU38OT000297-02NIAID NIH HHS R01 AI121129NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068635NIH HHS R01 AI121129NIH HHS UM1AI068635
6 · The paper itself

Abstract

Trial results for two COVID-19 vaccines suggest at least 90% efficacy against symptomatic disease (VE

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolCOVID-19COVID-19 VaccinesHospitalizationHumansInfantMiddle AgedSARS-CoV-2VaccinationYoung AdultCOVID-19 Vaccines

Identifiers

PMID34330945
PMCPMC8324774
OpenAlexW3190205441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.