ArticleNature communications2021
Lytic archaeal viruses infect abundant primary producers in Earth's crust.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Comprehensive analyses of archaeal viral genomes reveal genomic characteristics, divergence, and host interactions.Microbiome · 2026Article
- Microbial decomposer diversity and metabolic function during the decomposition of brine shrimp carcasses in a saline lake.Microbiome · 2026Article
- Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments.Nature communications · 2025Article
- Acquisition of Spacers from Foreign Prokaryotic Genomes by CRISPR-Cas Systems in Natural Environments.Genome biology and evolution · 2025Article
- Differential Expression of Core Metabolic Functions in Candidatus Altiarchaeum Inhabiting Distinct Subsurface Ecosystems.Environmental microbiology reports · 2025Article
- Novel viruses of Haloquadratum walsbyi expand the known archaeal virosphere of hypersaline environments.The ISME journal · 2025Article
- A global deep terrestrial biosphere core microbiome.ISME communications · 2025Article
- Metagenomic characterization of viruses and mobile genetic elements associated with the DPANN archaeal superphylum.Nature microbiology · 2024Article
- New Viruses Infecting Hyperthermophilic BacteriumViruses · 2024Article
- Unveiling the unknown viral world in groundwater.Nature communications · 2024Article
- Reply to: Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut.Nature communications · 2024Article
- Exploring the Archaeal Virosphere by Metagenomics.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Novel candidate taxa contribute to key metabolic processes in Fennoscandian Shield deep groundwaters.ISME communications · 2024Article
- Time-series metaproteogenomics of a high-COmicroLife · 2024Article
- Spatio-functional organization in virocells of small uncultivated archaea from the deep biosphere.The ISME journal · 2023Article
- A predicted CRISPR-mediated symbiosis between uncultivated archaea.Nature microbiology · 2023Article
- MArVD2: a machine learning enhanced tool to discriminate between archaeal and bacterial viruses in viral datasets.ISME communications · 2023Article
- The smallest in the deepest: the enigmatic role of viruses in the deep biosphere.National science review · 2023Review
- Virus-Host Dynamics in Archaeal Groundwater Biofilms and the Associated Bacterial Community Composition.Viruses · 2023Article
- Dark biosphere: Just at the very tip of the iceberg.Environmental microbiology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The continental subsurface houses a major portion of life's abundance and diversity, yet little is known about viruses infecting microbes that reside there. Here, we use a combination of metagenomics and virus-targeted direct-geneFISH (virusFISH) to show that highly abundant carbon-fixing organisms of the uncultivated genus Candidatus Altiarchaeum are frequent targets of previously unrecognized viruses in the deep subsurface. Analysis of CRISPR spacer matches display resistances of Ca. Altiarchaea against eight predicted viral clades, which show genomic relatedness across continents but little similarity to previously identified viruses. Based on metagenomic information, we tag and image a putatively viral genome rich in protospacers using fluorescence microscopy. VirusFISH reveals a lytic lifestyle of the respective virus and challenges previous predictions that lysogeny prevails as the dominant viral lifestyle in the subsurface. CRISPR development over time and imaging of 18 samples from one subsurface ecosystem suggest a sophisticated interplay of viral diversification and adapting CRISPR-mediated resistances of Ca. Altiarchaeum. We conclude that infections of primary producers with lytic viruses followed by cell lysis potentially jump-start heterotrophic carbon cycling in these subsurface ecosystems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.