Evidence map›Paper›PMID 34330825›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Fli1

Gianfranco Matrone, Bo Xia, Kaifu Chen, Martin A Denvir, Andrew H Baker, John P Cooke

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. A Combined HumanFrontiers in pharmacology · 2022
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Gianfranco MatroneCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030; gianfranco.matrone@ed.ac.uk.ORCID 0000-0001-7084-3546
Bo XiaCenter for Bioinformatics and Computational Biology, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030.
Kaifu ChenCenter for Bioinformatics and Computational Biology, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030.
Martin A DenvirBritish Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Andrew H BakerBritish Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.ORCID 0000-0003-1441-5576
John P CookeCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030.ORCID 0000-0003-0033-9138
Houston Methodist · USBritish Heart Foundation · GB

Funding

Reversal of Heart Failure: Role of Vascular RecoveryR01HL148338 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2020 to 2023
$2.8M
Role of S-nitrosylation in TransdifferentiationR01HL133254 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2018 to 2021
$1.6M
Computational epigenetics modeling of cell identity genesR01GM125632 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU · 2018 to 2021
$1.4M
British Heart Foundation CH/09/002British Heart Foundation CH/11/2/28733British Heart Foundation RE/13/3/30183British Heart Foundation RE/18/5/34216British Heart Foundation RG/16/10/32375British Heart Foundation RM/17/3/33381British Heart Foundation WT103782AIANHLBI NIH HHS R01 HL133254NHLBI NIH HHS R01 HL148338NIGMS NIH HHS R01 GM125632Wellcome Trust
6 · The paper itself

Abstract

A network of molecular factors drives the development, differentiation, and maintenance of endothelial cells. Friend leukemia integration 1 transcription factor (FLI1) is a bona fide marker of endothelial cells during early development. In zebrafish

Indexed as

AnimalsAnimals, Genetically ModifiedCell DifferentiationDNA-Binding ProteinsEmbryo, NonmammalianEndothelial CellsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHumansInduced Pluripotent Stem CellsNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1Proto-Oncogene Protein c-fli-1RNA-SeqTranscriptomeUp-RegulationDNA-Binding ProteinsGreen Fluorescent ProteinsPlatelet Endothelial Cell Adhesion Molecule-1prdm16 protein, zebrafishProto-Oncogene Protein c-fli-1Zebrafish Proteinsangiogenesisdifferentiationendothelial cellsepigenetic factorszebrafish

Identifiers

PMID34330825
PMCPMC8346798
OpenAlexW3185643407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.