Evidence map›Paper›PMID 34330822›Full record

ArticleMolecular pharmacology2021

Ligand-Independent G Protein-Coupled Estrogen Receptor/G Protein-Coupled Receptor 30 Activity: Lack of Receptor-Dependent Effects of G-1 and 17

Julia Tutzauer, Ernesto Gonzalez de Valdivia, Karl Swärd, Ioannis Alexandrakis Eilard, Stefan Broselid, Robin Kahn, Björn Olde, L M Fredrik Leeb-Lundberg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. GPER: An Estrogen Receptor Key in Metastasis and Tumoral Microenvironments.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Julia TutzauerDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
Ernesto Gonzalez de ValdiviaDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
Karl SwärdDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
Ioannis Alexandrakis EilardDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
Stefan BroselidDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
Robin KahnDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
Björn OldeDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.
L M Fredrik Leeb-LundbergDepartment of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden fredrik.leeb-lundberg@med.lu.se.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G protein-coupled receptor 30 (GPR30) is a membrane receptor reported to bind 17

Indexed as

AnimalsArteriesCell LineCyclopentanesDisks Large Homolog 4 ProteinEstradiolFemaleHumansLigandsMiceMice, Inbred C57BLMice, KnockoutMuscle RelaxationPDZ DomainsQuinolinesReceptors, Estrogen1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanoneCyclopentanesDisks Large Homolog 4 ProteinEstradiolGPER1 protein, humanGPER1 protein, mouseLigandsQuinolinesReceptors, EstrogenReceptors, G-Protein-Coupled

Identifiers

PMID34330822
PMCPMC8626787
OpenAlexW3183328706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.