ArticleeNeuro
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Distinct types of dendritic CaScience advances · 2026Article
- Precise calcium-to-spike inference using biophysical generative models.bioRxiv : the preprint server for biology · 2026Article
- Astrocyte-induced dynamics of a pyramidal cell with a dendrite-connected astrocyte.Journal of computational neuroscience · 2026Article
- Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit.Nature communications · 2026Article
- Article
- Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity.PLoS computational biology · 2025Article
- Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution.Communications biology · 2025Article
- Precise calcium-to-spike inference using biophysical generative models.Research square · 2025Article
- Article
- Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus.Nature neuroscience · 2024Article
- Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation.iScience · 2023Article
- Phase information is conserved in sparse, synchronous population-rate-codes via phase-to-rate recoding.Nature communications · 2023Article
- Effective and efficient neural networks for spike inference fromCell reports methods · 2023Article
- Article
- Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals.Science advances · 2023Article
- Article
- Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences.Neuron · 2022Article
- Article
- Assessing Local and Branch-specific Activity in Dendrites.Neuroscience · 2022Article
- A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging.Nature neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal population activity in the hippocampal CA3 subfield is implicated in cognitive brain functions such as memory processing and spatial navigation. However, because of its deep location in the brain, the CA3 area has been difficult to target with modern calcium imaging approaches. Here, we achieved chronic two-photon calcium imaging of CA3 pyramidal neurons with the red fluorescent calcium indicator R-CaMP1.07 in anesthetized and awake mice. We characterize CA3 neuronal activity at both the single-cell and population level and assess its stability across multiple imaging days. During both anesthesia and wakefulness, nearly all CA3 pyramidal neurons displayed calcium transients. Most of the calcium transients were consistent with a high incidence of bursts of action potentials (APs), based on calibration measurements using simultaneous juxtacellular recordings and calcium imaging. In awake mice, we found state-dependent differences with striking large and prolonged calcium transients during locomotion. We estimate that trains of >30 APs over 3 s underlie these salient events. Their abundance in particular subsets of neurons was relatively stable across days. At the population level, we found that co-activity within the CA3 network was above chance level and that co-active neuron pairs maintained their correlated activity over days. Our results corroborate the notion of state-dependent spatiotemporal activity patterns in the recurrent network of CA3 and demonstrate that at least some features of population activity, namely co-activity of cell pairs and likelihood to engage in prolonged high activity, are maintained over days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.