ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Learning and Representation of Hierarchical Concepts in Hippocampus and Prefrontal Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dorsomedial prefrontal cortex links abstract planning to motor execution.Communications biology · 2026Article
- Cortical knowledge structures guide word concept learning.Nature communications · 2026Article
- Distinct Hippocampal Mechanisms Support Concept Formation and Updating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Distinct contributions of hippocampal pathways in learning regularities and exceptions revealed by functional footprints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mental graphs structure the storage and retrieval of visuomotor associations.Nature human behaviour · 2025Article
- Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation.PLoS computational biology · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Emergence of Categorical Representations in Parietal and Ventromedial Prefrontal Cortex across Extended Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Category boundaries modulate memory in a place-cell-like manner.Current biology : CB · 2024Article
- Reconciling category exceptions through representational shifts.Psychonomic bulletin & review · 2024Article
- Discrimination of semantically similar verbal memory traces is affected in healthy aging.Scientific reports · 2024Article
- Event Integration and Temporal Differentiation: How Hierarchical Knowledge Emerges in Hippocampal Subfields through Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hierarchical categorization learning is associated with representational changes in the dorsal striatum and posterior frontal and parietal cortex.Human brain mapping · 2023Article
- Article
- Is love an abstract concept? A view of concepts from an interaction-based perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- What Does the Frontopolar Cortex Contribute to Goal-Directed Cognition and Action?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key aspect of conceptual knowledge is that it can be flexibly applied at different levels of abstraction, implying a hierarchical organization. It is yet unclear how this hierarchical structure is acquired and represented in the brain. Here we investigate the computations underlying the acquisition and representation of the hierarchical structure of conceptual knowledge in the hippocampal-prefrontal system of 32 human participants (22 females). We assessed the hierarchical nature of learning during a novel tree-like categorization task via computational model comparisons. The winning model allowed to extract and quantify estimates for accumulation and updating of hierarchical compared with single-feature-based concepts from behavior. We find that mPFC tracks accumulation of hierarchical conceptual knowledge over time, and mPFC and hippocampus both support trial-to-trial updating. As a function of those learning parameters, mPFC and hippocampus further show connectivity changes to rostro-lateral PFC, which ultimately represented the hierarchical structure of the concept in the final stages of learning. Our results suggest that mPFC and hippocampus support the integration of accumulated evidence and instantaneous updates into hierarchical concept representations in rostro-lateral PFC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.