SynthesisJournal of pediatric surgery2022
Optimal timing for Soave primary pull-through in short-segment Hirschsprung disease: A meta-analysis.
Synthesis in Journal of pediatric surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Perioperative outcomes in primary neonatal pullthrough versus pullthrough in older children with Hirschsprung disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Evaluation of Trans-Anal Endorectal Pull-Through Outcomes in Hirschsprung's Disease in Different Age Groups: A Comprehensive Systematic Review.Archives of Iranian medicine · 2024Pooled it
- Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial.Nature communications · 2025Trial
- Perioperative and Long-Term Functional Outcomes of Children With Early Diagnosis Versus Late Diagnosis of Hirschsprung's Disease: A 30-Year Monocentric Retrospective Study.International journal of pediatrics · 2026Article
- Safety and feasibility of one-stage neonatal approach for short-segment Hirschsprung's disease.PloS one · 2026Article
- Perioperative outcomes of neonatal versus delayed surgery for Hirschsprung disease: a nationwide retrospective cohort study in Japan.Pediatric surgery international · 2025Article
- For short-segment Hirschsprung disease, daily trans-anal irrigation before pull-through surgery is necessary?Pediatric research · 2025Article
- Management of Hirschsprung's Disease: A Survey with Brazilian Pediatric Surgeons.Children (Basel, Switzerland) · 2024Article
- Surgical outcomes for patients with rectosigmoid hirschsprung disease who underwent transanal endorectal pull-through after 1 year of age.BMC surgery · 2024Article
- Early intervention in Hirschsprung's disease: effects on enterocolitis and surgical outcomes.BMC pediatrics · 2024Article
- Pullthrough pitfalls in treating Hirschsprung disease.World journal of pediatric surgery · 2024Article
- Controversies in Hirschsprung surgery.World journal of pediatric surgery · 2024Review
- Surgical management of short-segment Hirschsprung disease.World journal of pediatric surgery · 2024Review
- Hirschsprung disease.Nature reviews. Disease primers · 2023Review
- Comparation of robotic-assisted surgery and laparoscopic‑assisted surgery in children with Hirschsprung's disease: a single-centered retrospective study.BMC surgery · 2023Article
- Prognostic factors for persistent obstructive symptoms in patients with Hirschsprung disease following pull-through.PloS one · 2023Article
- Screening of undernutrition in children with Hirschsprung disease using preoperative anthropometric parameters: A multicenter cross-sectional study.JPEN. Journal of parenteral and enteral nutrition · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe optimal age for endorectal pull-through (ERPT) surgery in infants with short-segment Hirschsprung disease varies, with a trend toward earlier surgery. However, it is unclear if the timing of surgery impacts functional outcomes. We undertook the present study to determine the optimal timing of ERPT in infants with short-segment Hirschsprung disease.
methodsThe NCBI PubMed database was searched for English-language manuscripts published between 2000 and 2019 analyzing functional outcomes for patient following the initial Soave ERPT for short-segment Hirschsprung disease. Raw data from these studies was obtained from the corresponding author for each manuscript. We combined data from these papers with our own institutional data and performed a meta-analysis.
resultsA total of 780 infants were included in our meta-analysis. Constipation occurred in 1.0-31.7%, soiling 1.3-26.0%, anastomotic stricture 0.0-14.6%, and anastomotic leak 0.0-3.4%. Regarding age at ERPT, younger infants at the time of initial corrective surgery had higher rates of soiling, stricture, and leak. On sub-group analysis, patients <2.5 months at their initial corrective surgery had higher rates of soiling (25.9% vs. 11.4%, p<0.01), as well as stricture (10.0% vs 1.7%, p<0.01) and leak (5.5% vs 1.3%, p<0.01).
conclusionWhile age at Soave endorectal pull-through for short-segment Hirschsprung disease has decreased over time, functional outcomes associated with this trend have only recently been examined. Our findings suggest that patients <2.5 months old at the time of endorectal pull-through may have worse functional outcomes, emphasizing the need to consider further study of the timing of surgery in this population.
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