Evidence map›Paper›PMID 34329810›Full record

ArticleClinical neurology and neurosurgery2021

Myasthenia gravis associated with novel coronavirus 2019 infection: A report of three cases.

Narges Karimi, Ali Asghar Okhovat, Bentolhoda Ziaadini, Bahram Haghi Ashtiani, Shahriar Nafissi, Farzad Fatehi

Open access · greenAbstract readCase Reports
In one paragraph

Article in Clinical neurology and neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

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  9. Autoimmune myasthenia gravis and COVID-19. A case report-based review.The Journal of international medical research · 2023
    Review
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  16. SeronegativeVeterinary sciences · 2022
    Article
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  20. The relationship between myasthenia gravis and COVID-19: a systematic review.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Narges KarimiDepartment of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurology, Clinical Research Development Unit of Bou Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Ali Asghar OkhovatDepartment of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Bentolhoda ZiaadiniDepartment of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Bahram Haghi AshtianiDepartment of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Shahriar NafissiDepartment of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Farzad FatehiDepartment of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: fatehifa@gmail.com.
Shariati Hospital · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several neurological presentations have been reported following coronavirus 2019 (COVID-19) infection. This case report describes three myasthenia gravis (MG) patients presented following COVID-19 infection. We report three adult patients with myasthenic Gravis and COVID-19 infection. The patients are between 38 and 61 years old. Case 1 is a 61-year-old woman with progressive dysphagia, nasal speech, ocular ptosis, diplopia, and proximal muscle weakness for 10 days. She had a COVID-19 infection 6 weeks ago. Case 2 is a 57-year-old man with clinical symptoms of muscular fatigability, diplopia, ptosis, and dysphagia for a week and a positive COVID-19 infection 10 days ago. Case 3 is a 38-year-old woman with fatigability, ptosis, dysphagia, and a diagnosis of COVID-19 infection 4 weeks ago. All patients had a positive RT-PCR for COVID-19 infection by nasopharyngeal swab test and a high-level acetylcholine receptor antibody in the serum. All patients were treated with pyridostigmine and prednisolone with a favorable outcome. MG may appear following COVID-19 infection, and the role of molecular mimicry and latent MG activation should be considered the cause of the disease onset.

Indexed as

AdultAnti-Inflammatory AgentsAutoantibodiesAutoantigensCholinesterase InhibitorsCOVID-19FemaleHumansMaleMiddle AgedMyasthenia GravisPrednisoloneReceptors, CholinergicSARS-CoV-2Anti-Inflammatory AgentsAutoantibodiesAutoantigensCholinesterase InhibitorsPrednisoloneReceptors, CholinergicCase reportCoronavirus 2019COVID-19Myasthenia gravisPost-infection

Identifiers

PMID34329810
PMCPMC8299214
OpenAlexW3183558928

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.