Evidence map›Paper›PMID 34329585›Full record

ArticleCancer cell2021

Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy.

Stephen L Shiao, Kathleen M Kershaw, Jose J Limon, Sungyong You, Junhee Yoon, Emily Y Ko, Jlenia Guarnerio, Alka A Potdar, Dermot P B McGovern, Shikha Bose and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 1 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 1 synthesis or guideline pooled it, 262 citations in OpenAlex.

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  20. Microbiota in cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Stephen L ShiaoDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: stephen.shiao@cshs.org.
Kathleen M KershawDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jose J LimonF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sungyong YouDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Junhee YoonDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Emily Y KoDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Jlenia GuarnerioDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Alka A PotdarF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Dermot P B McGovernF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Shikha BoseDepartment of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Tahir B DarDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Paul NoeDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Jung LeeDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Yuzu KubotaDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Viviana I MaymiDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Madison J DavisDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Regina M HensonDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Rachel Y ChoiDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Wensha YangDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Jie TangGenomics Core, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Matthew GargusF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Alexander D PrinceF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Zachary S ZumstegDepartment of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
David M UnderhillDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Cedars-Sinai Medical Center · US

Funding

Host immunity to commensal gut fungiR01DK093426 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI UNDERHILL, DAVID M. · 2012 to 2021
$3.7M
Impact of the Microbiome on the Efficacy of Radiation TherapyR01CA220000 · NCI · CEDARS-SINAI MEDICAL CENTER · PI SHIAO, STEPHEN L. · 2017 to 2021
$1.7M
MIF: a pro-inflammatory cytokine as a novel target to reduce bladder inflammationR01DK093496 · NIDDK · LEXINGTON BIOMEDICAL RESEARCH INSTITUTE · PI VERA, PEDRO L · 2012 to 2016
$1.2M
The Impact of Macrophage Polarization on the Efficacy of Radiation TherapyK08CA191139 · NCI · CEDARS-SINAI MEDICAL CENTER · PI SHIAO, STEPHEN L. · 2015 to 2019
$884k
Investigation and functional characterization of new drivers of mesenchymal tumorigenesis.R00CA212200 · NCI · CEDARS-SINAI MEDICAL CENTER · PI GUARNERIO, JLENIA · 2018 to 2020
$710k
NCI NIH HHS K08 CA191139NCI NIH HHS R00 CA212200NCI NIH HHS R01 CA220000NIDDK NIH HHS R01 DK093426NIDDK NIH HHS R01 DK093496
6 · The paper itself

Abstract

Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on radiation therapy is not as well understood, and the microbiome comprises more than bacteria. Here, we find that intestinal fungi regulate antitumor immune responses following radiation in mouse models of breast cancer and melanoma and that fungi and bacteria have opposite influences on these responses. Antibiotic-mediated depletion or gnotobiotic exclusion of fungi enhances responsiveness to radiation, whereas antibiotic-mediated depletion of bacteria reduces responsiveness and is associated with overgrowth of commensal fungi. Further, elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in patients with breast cancer and is required for the effects of commensal fungi in mouse models of radiation therapy.

Indexed as

AnimalsAntifungal AgentsBacteriaBreast NeoplasmsCombined Modality TherapyDectin-1Down-RegulationFemaleFungiGastrointestinal MicrobiomeGene Expression Regulation, NeoplasticHumansLectins, C-TypeMelanomaMiceSymbiosisAntifungal AgentsCLEC7A protein, humanDectin-1Lectins, C-Typebacteriadectin-1fungiimmunotherapymacrophagesmicrobiomemycobiomeradiationT cellstumor immunology

Identifiers

PMID34329585
PMCPMC8830498
OpenAlexW3185806288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.