Evidence map›Paper›PMID 34329411›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Donor-derived Ehrlichiosis: 2 Clusters Following Solid Organ Transplantation.

Aditi Saha, Charles Browning, Raja Dandamudi, Kevin Barton, Kevin Graepel, Madeline Cullity, Wala Abusalah, Du Christine, Carla Rossi, Naomi Drexler and 10 more

Open access · greenAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  7. Article
  8. Transmission of Ehrlichia chaffeensis From an Organ Donor to a Kidney-Pancreas Transplant Recipient.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Aditi SahaRenal and Pancreas Transplant Division and Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
Charles BrowningDepartment of Transplant Surgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.
Raja DandamudiDivision of Pediatric Nephrology, Washington University of Medicine, St. Louis, Missouri, USA.
Kevin BartonDivision of Pediatric Nephrology, Washington University of Medicine, St. Louis, Missouri, USA.
Kevin GraepelDivision of Pediatric Nephrology, Washington University of Medicine, St. Louis, Missouri, USA.
Madeline CullityDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Wala AbusalahRenal and Pancreas Transplant Division and Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
Du ChristineDepartment of Transplant Surgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.
Carla RossiDepartment of Infectious Disease, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.
Naomi DrexlerRickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sridhar V BasavarajuDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Pallavi AnnambhotiaDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Rodrigo Vazquez GuillametDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Albert J EidDivision of Infectious Diseases, University of Kansas Medical Center, Kansas City, Kansas, USA.
Joseph MaliakkalDivision of Pediatric Nephrology, Saint Louis University, Missouri, USA.
Aaron MillerDivision of Pediatric Infectious Disease, Saint Louis University, Missouri, USA.
Christopher HuggeDivision of Pediatric Hematology Oncology, Saint Louis University, Missouri, USA.
Vikas R DharnidharkaDivision of Pediatric Nephrology, Washington University of Medicine, St. Louis, Missouri, USA.
Praveen KandulaRenal and Pancreas Transplant Division and Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
Michael J MoritzDepartment of Transplant Surgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.
Washington University in St. Louis · USLehigh Valley Health Network · USSaint Barnabas Medical Center · USSaint Louis University · USCenters for Disease Control and Prevention · USNational Center for Emerging and Zoonotic Infectious Diseases · USUniversity of Kansas Medical Center · US

Funding

National Institute of Allergy and Infectious DiseasesNIDDK NIH HHS
6 · The paper itself

Abstract

Ehrlichiosis has been infrequently described as transmissible through organ transplantation. Two donor-derived clusters of ehrlichiosis are described here. During the summer of 2020, 2 cases of ehrlichiosis were reported to the Organ Procurement and Transplantation Network (OPTN) and the Centers for Disease Control and Prevention (CDC) for investigation. Additional transplant centers were contacted to investigate similar illness in other recipients and samples were sent to the CDC. Two kidney recipients from a common donor developed fatal ehrlichiosis-induced hemophagocytic lymphocytic histiocytosis. Two kidney recipients and a liver recipient from another common donor developed ehrlichiosis. All 3 were successfully treated. Clinicians should consider donor-derived ehrlichiosis when evaluating recipients with fever early after transplantation after more common causes are ruled out, especially if the donor has epidemiological risk factors for infection. Suspected cases should be reported to the organ procurement organization and the OPTN for further investigation by public health authorities.

Indexed as

EhrlichiosisKidney TransplantationOrgan TransplantationTissue and Organ ProcurementHumansTissue DonorsDDIdeceased donorehrlichiosishemophagocytic lymphocytic histiocytosisHLHinfectiontickstransplantation

Identifiers

PMID34329411
PMCPMC8906657
OpenAlexW3185782541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.