ArticlePLoS neglected tropical diseases2021
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.
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Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques.Nature communications · 2026Article
- Multi-antigen DNA vaccine targeting non-structural proteins confers robust T Cell-mediated protection against Zika virus.NPJ vaccines · 2026Article
- Sub-neutralizing concentrations of Zika virus IgM monoclonal antibodies reduce IgG-mediated antibody-dependent enhancement of infectivity.bioRxiv : the preprint server for biology · 2026Article
- Zika virus and the fetal-maternal interface: deciphering the mechanisms of placental infection and implications for pregnancy outcomes.Emerging microbes & infections · 2025Review
- CD4Vaccines · 2025Article
- Pre-existing YFV-17D immunity mediates T cell cross-protection against dengue virus serotype 2 infection in mice.Communications biology · 2025Article
- Review
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
- Yellow Jack: a modern threat to Asia-Pacific countries?Npj viruses · 2025Review
- Macaque Models of Prenatal and Postnatal Zika Virus Exposure and Developmental Outcomes.Journal of the Pediatric Infectious Diseases Society · 2025Review
- Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface.Memorias do Instituto Oswaldo Cruz · 2025Review
- Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection.NPJ vaccines · 2024Article
- Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024Review
- Evaluation of Thiazolidine Derivatives with Potential Anti-ZIKV Activity.Current topics in medicinal chemistry · 2024Article
- Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model.PLoS pathogens · 2023Article
- Prior COVID-19 Immunization Does Not Cause IgA- or IgG-Dependent Enhancement of SARS-CoV-2 Infection.Vaccines · 2023Article
- Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus.PLoS pathogens · 2023Article
- Control of maternal Zika virus infection during pregnancy is associated with lower antibody titers in a macaque model.Frontiers in immunology · 2023Article
- Comparative Analysis of In Vitro Models to Study Antibody-Dependent Enhancement of Zika Virus Infection.Viruses · 2022Article
- Transplacental Zika virus transmission in ex vivo perfused human placentas.PLoS neglected tropical diseases · 2022Article
Corrections and comments
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Authors and funding
33 authors at 5 institutions in 1 country.
Chelsea M CrooksDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-3874-4577
Andrea M WeilerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-7130-8235
Sierra L RybarczykWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-3564-9750
Mason I BlissWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-0433-4211
Anna S JaegerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, St. Paul, Minnesota, United States of America.
Megan E MurphyDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-4862-7289
Andres MejiaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0001-6088-3595
Michael K FritschDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Jennifer M HayesWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Jens C EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Ann M MitzeyDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-3394-9656
Elaina RazoDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Katarina M BraunDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-3612-9319
Elizabeth A BrownDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Keisuke YamamotoDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0001-6118-7559
Phoenix M ShepherdDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Amber PossellWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Kara WeaverWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Kathleen M AntonyDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-3537-8030
Terry K MorganDepartment of Pathology, Oregon Health and Science University, Portland, Oregon, United States of America.
Christina M NewmanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-8749-4378
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-0934-2042
Nancy Schultz-DarkenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Eric PetersonWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-5093-0631
Leah C KatzelnickDivision of Infectious Diseases and Vaccinology, University of California Berkeley, Berkeley, California, United States of America.
Angel BalmasedaSustainable Sciences Institute, Managua, Nicaragua.
Eva HarrisDivision of Infectious Diseases and Vaccinology, University of California Berkeley, Berkeley, California, United States of America.ORCID 0000-0002-7238-4037
David H O'ConnorWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-2139-470X
Emma L MohrDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-0742-305X
Thaddeus G GolosWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-7897-4337
Thomas C FriedrichDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0001-9831-6895
Matthew T AliotaDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, St. Paul, Minnesota, United States of America.ORCID 0000-0002-6902-9149
University of Wisconsin–Madison · USUniversity of California, Berkeley · USUniversity of Minnesota · USOregon Health & Science University · USSustainable Sciences Institute · US
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MT Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Eva Harris · 2015 to 2026
$34.1MINTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3MZika virus pathophysiology during pregnancyP01AI132132 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$10.2MIntegrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5MParasitology and Vector Biology Training ProgramT32AI007414 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Lyric Colleen Bartholomay · 1992 to 2026
$4.5MPrevious exposure to dengue as a risk factor for Zika during pregnancyR01AI132563 · NIAID · UNIVERSITY OF MINNESOTA · PI ALIOTA, MATTHEW T · 2018 to 2022
$2.8MDefining maternal and neonatal antibody responses in congenital Zika virus infectionK08AI139341 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MOHR, EMMA L · 2019 to 2023
$1.0MDefining the role of genetic drift in within-host influenza evolutionF30AI145182 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRAUN, KATARINA M · 2020 to 2022
$95kNIAID NIH HHS F30 AI145182NIAID NIH HHS K08 AI139341NIAID NIH HHS P01 AI106695NIAID NIH HHS P01 AI132132NIAID NIH HHS R01 AI132563NIAID NIH HHS T32 AI007414NIGMS NIH HHS T32 GM008692NIGMS NIH HHS T32 GM140935NIH HHS P51 OD011106
Abstract
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate.
Indexed as
Dengue VirusMaternal-Fetal ExchangeZika VirusAnimalsAntibodies, ViralAntigens, ViralDengueFemaleInfectious Disease Transmission, VerticalPlacentaPregnancyRNA, ViralVirus ReplicationZika Virus InfectionAntibodies, ViralAntigens, ViralRNA, Viral
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