Evidence map›Paper›PMID 34329193›Full record

ArticleAging2021

CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis.

Wei Zhang, Hui Liu, Junjie Jiang, Yunyun Yang, Wenjie Wang, Zhengyan Jia

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Hsa_circ_0101308 adjusted by N6-methyladenosine (mCancer biomarkers : section A of Disease markers · 2025
    Article
  4. Article
  5. A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Noncoding RNAs, Vital Players in Breast Cancer Metastasis.Breast cancer (Dove Medical Press) · 2025
    Review
  9. Review
  10. The emerging role and mechanism of HMGA2 in breast cancer.Journal of cancer research and clinical oncology · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wei ZhangDepartment of Thyroid and Breast I, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
Hui LiuDepartment of Thyroid and Breast I, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
Junjie JiangDepartment of Thyroid and Breast I, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
Yunyun YangOutpatient Comprehensive Treatment, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
Wenjie WangDepartment of General Surgery, Botou Hospital, Botou, Hebei Province, China.
Zhengyan JiaDepartment of General Surgery, Qingxian People's Hospital, Qingxian, Hebei Province, China.
Cangzhou Central Hospital · CNCixian People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis is the leading cause of breast cancer (BC)-related deaths. Circular RNAs (circRNAs) have emerged as essential regulators for cancer progression and metastasis. Therefore, the objective of this study was to investigate the role of circRNAs in BC metastasis and related mechanism. In this study, we established the BC cell line with high or low potential of metastasis. RNA sequencing, migration and invasion assay, Fluorescence

Indexed as

AnimalsBreast NeoplasmsCarcinogenesisCell Line, TumorExosomesFemaleForkhead Transcription FactorsGene Expression Regulation, NeoplasticHumansIn Situ Hybridization, FluorescenceMiceMice, Inbred BALB CMice, NudeMicroRNAsNeoplasm MetastasisRNA-Binding ProteinsForkhead Transcription FactorsIGF2BP3 protein, humaninterleukin binding factorMicroRNAsMIRN370 microRNA, humanRNA-Binding ProteinsRNA, Circularbreast cancercircFOXK2IGF2BP3metastasismiR-370

Identifiers

PMID34329193
PMCPMC8351678
OpenAlexW3184037783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.