ArticleIEEE transactions on medical imaging2021
Quantitative Biomarkers for Cancer Detection Using Contrast-Free Ultrasound High-Definition Microvessel Imaging: Fractal Dimension, Murray's Deviation, Bifurcation Angle & Spatial Vascularity Pattern.
Article in IEEE transactions on medical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Multiscale OCTA framework for assessing choriocapillaris flow-void organisation in chronic central serous chorioretinopathy using a vascular coalescence index.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Differential peritoneal resident macrophage depletion and omental milky spot disruption after high versus low clodronate-loaded liposome dose treatment.Immunology and cell biology · 2026Article
- Abnormal vasculature reduces overlap between drugs and oxygen in a tumour computational model: Implications for therapeutic efficacy.PLoS computational biology · 2025Article
- Quantitative microvessel orientation biomarkers derived from contrast free ultrasound imaging for cancer diagnosis.Scientific reports · 2025Article
- Deep learning based motion correction in ultrasound microvessel imaging approach improves thyroid nodule classification.Scientific reports · 2025Article
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- Advancing insights: a bibliometric analysis of evolutionary patterns and research frontiers in ultrasound-derived quantitative assessment of skeletal muscle.Quantitative imaging in medicine and surgery · 2025Article
- Ultrasound-based quantitative microvasculature imaging for early prediction of response to neoadjuvant chemotherapy in patients with breast cancer.Breast cancer research : BCR · 2025Article
- Fast inter-frame motion correction in contrast-free ultrasound quantitative microvasculature imaging using deep learning.Scientific reports · 2024Article
- Article
- Background Noise Removal in Non-Contrast- Enhanced Ultrasound Microvasculature Imaging Using Combined Collaborative, Morphological, and Vesselness Filtering.IEEE access : practical innovations, open solutions · 2024Article
- Diagnostic performance of contrast-enhanced ultrasound in breast lesions: what diagnostic models could be used for lesions of different sizes?Gland surgery · 2023Article
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- Contrast-free ultrasound imaging for blood flow assessment of the lower limb in patients with peripheral arterial disease: a feasibility study.Scientific reports · 2023Article
- Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach.Breast cancer research : BCR · 2023Article
- Article
- Morphometric analysis of tumor microvessels for detection of hepatocellular carcinoma using contrast-free ultrasound imaging: A feasibility study.Frontiers in oncology · 2023Article
- Volumetric imaging and morphometric analysis of breast tumor angiogenesis using a new contrast-free ultrasound technique: a feasibility study.Breast cancer research : BCR · 2022Article
- Hybrid high-definition microvessel imaging/shear wave elastography improves breast lesion characterization.Breast cancer research : BCR · 2022Article
- Association Between Retinal Microvascular Metrics Using Optical Coherence Tomography Angiography and Carotid Artery Stenosis in a Chinese Cohort.Frontiers in physiology · 2022Article
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6 authors.
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Abstract
A growing body of evidence indicates that there is a strong correlation between microvascular morphological features and malignant tumors. Therefore, quantification of these features might allow more accurate differentiation of benign and malignant tumors. The main objective of this research project is to improve the quantification of microvascular networks depicted in contrast-free ultrasound microvessel images. To achieve this goal, a new series of quantitative microvessel morphological parameters are introduced for differentiation of breast masses using contrast-free ultrasound-based high-definition microvessel imaging (HDMI). Using HDMI, we quantified and analyzed four new parameters: 1) microvessel fractal dimension (mvFD), a marker of tumor microvascular complexity; 2) Murray's deviation (MD), the diameter mismatch, defined as the deviation from Murray's law; 3) bifurcation angle (BA), abnormally decreased angle; and 4) spatial vascular pattern (SVP), indicating tumor vascular distribution pattern, either intratumoral or peritumoral. The new biomarkers have been tested on 60 patients with breast masses. Validation of the feature's extraction algorithm was performed using a synthetic data set. All the proposed parameters had the power to discriminate the breast lesion malignancy (p < 0.05), displaying BA as the most sensitive test, with a sensitivity of 90.6%, and mvFD as the most specific test, with a specificity of 92%. The results of all four new biomarkers showed an AUC = 0.889, sensitivity of 80% and specificity of 91.4% In conclusion, the added value of the proposed quantitative morphological parameters, as new biomarkers of angiogenesis within breast masses, paves the way for more accurate breast cancer detection with higher specificity.
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