Evidence map›Paper›PMID 34328821›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021

High prevalence of comorbidities at diagnosis in immigrants with multiple sclerosis.

Dalia Rotstein, Colleen Maxwell, Karen Tu, Jodi Gatley, Priscila Pequeno, Alexander Kopp, Ruth Ann Marrie

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. The Barancik lecture: Comorbidity in multiple sclerosis-Looking backward, looking forward.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023
    Article
  3. Enhancing diversity of clinical trial populations in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Characterizing the diversity of the multiple sclerosis population in Canada: A scoping review.Multiple sclerosis journal - experimental, translational and clinical
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Dalia RotsteinDepartment of Medicine, University of Toronto, Toronto, ON, Canada/St. Michael's Hospital, Toronto, ON, Canada.
Colleen MaxwellSchools of Pharmacy and Public Health and Health Systems, University of Waterloo, Waterloo, ON, Canada/ICES, Toronto, ON, Canada.
Karen TuNorth York General Hospital, Toronto, ON, Canada/Department of Family and Community Medicine and Institute for Health Policy and Management, University of Toronto, Toronto, ON, Canada/Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Jodi GatleyICES, Toronto, ON, Canada.
Priscila PequenoICES, Toronto, ON, Canada.
Alexander KoppICES, Toronto, ON, Canada.
Ruth Ann MarrieDepartments of Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-1855-5595
St. Michael's Hospital · CAUniversity Health Network · CAUniversity of Manitoba · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) has been associated with certain comorbidities in general population studies, but it is unknown how comorbidity may affect immigrants with MS.

objectiveTo compare prevalence of comorbidities in immigrants and long-term residents at MS diagnosis, and in matched control populations without MS.

methodsWe identified incident MS cases using a validated definition applied to health administrative data in Ontario, Canada, from 1994 to 2017, and categorized them as immigrants or long-term residents. Immigrants and long-term residents without MS (controls) were matched to MS cases 3:1 on sex, age, and geography.

resultsThere were 1534 immigrants and 23,731 long-term residents with MS matched with 4585 and 71,193 controls, respectively. Chronic obstructive pulmonary disease (COPD), diabetes, hypertension, ischemic heart disease, migraine, epilepsy, mood/anxiety disorders, schizophrenia, inflammatory bowel disease (IBD), and rheumatoid arthritis were significantly more prevalent among immigrants with MS compared to their controls. Prevalence of these conditions was generally similar comparing immigrants to long-term residents with MS, although COPD, epilepsy, IBD, and mood/anxiety disorders were less prevalent in immigrants.

conclusionImmigrants have a high prevalence of multiple comorbidities at MS diagnosis despite the "healthy immigrant effect." Clinicians should pay close attention to identification and management of comorbidity in immigrants with MS.

Indexed as

Emigrants and ImmigrantsMultiple SclerosisComorbidityHumansOntarioPrevalencecomorbidityimmigrantsMultiple sclerosisprevalence

Identifiers

PMID34328821
PMCPMC8521357
OpenAlexW3185484305

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.