Evidence map›Paper›PMID 34328679›Full record

ArticleArthritis care & research2023

Musculoskeletal Ultrasound in Childhood Arthritis Limited Examination: A Comprehensive, Reliable, Time-Efficient Assessment of Synovitis.

Patricia Vega-Fernandez, Tracy V Ting, Edward J Oberle, Courtney McCracken, Janet Figueroa, Mekibib Altaye, Amy Cassedy, Gurjit S Kaeley, Johannes Roth, CARRA Musculoskeletal Ultrasound Workgroup

Open access · greenAbstract read
In one paragraph

Article in Arthritis care & research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 17 citations in OpenAlex.

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  10. Sonographic and Disease Activity Findings Related With Medication Change in JIA: A Historical Cohort Study.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Patricia Vega-FernandezCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-4911-7256
Tracy V TingCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Edward J OberleNationwide Children's Hospital and The Ohio State University, Columbus.ORCID 0000-0003-2171-9340
Courtney McCrackenEmory University School of Medicine, Atlanta, Georgia.
Janet FigueroaEmory University School of Medicine, Atlanta, Georgia.
Mekibib AltayeCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Amy CassedyCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Gurjit S KaeleyUniversity of Florida, Jacksonville.
Johannes RothChildren's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
CARRA Musculoskeletal Ultrasound Workgroup
Cincinnati Children's Hospital Medical Center · USEmory University · USChildren's Hospital of Eastern Ontario · CANationwide Children's Hospital · USUniversity of Florida · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)P30AR076316 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUNNER, HERMINE I · 2019 to 2023
$3.4M
NCATS NIH HHS KL2 TR001426NCATS NIH HHS UL1 TR001425NIAMS NIH HHS P30 AR076316
6 · The paper itself

Abstract

objectiveTo develop and initially validate a comprehensive pediatric musculoskeletal ultrasound (MSUS) joint-specific scoring system, and to determine the minimum number of joints needed to identify active disease.

methodsA semiquantitative scoring system was developed by consensus and initially validated by interrater reliability using intraclass correlation coefficients (ICCs). Subsequently, newly diagnosed juvenile idiopathic arthritis patients with an active joint count of >4 had a 42-joint MSUS performed at baseline and 3 months using this protocol. A minimum set of joints needed to identify all patients with synovitis on MSUS was obtained through a data reduction process. Spearman's correlation (r

resultsThe final joint-specific scoring system revealed an excellent interrater reliability (ICC 0.81-0.96) for all joints. Thirty patients were enrolled. Scanning 5 joints bilaterally (wrists, second and third metacarpophalangeal joints, knees and ankles) captured 100% of children with B-mode synovitis and had moderate correlation with the cJADAS10 at baseline (r

conclusionA limited MSUS examination called musculoskeletal ultrasound in childhood arthritis limited examination (MUSICAL) captures all patients with active synovitis, and our new joint-specific scoring system is highly reliable and sensitive to change.

Indexed as

Arthritis, JuvenileArthritis, RheumatoidSynovitisChildHumansReproducibility of ResultsUltrasonography

Identifiers

PMID34328679
PMCPMC8800943
OpenAlexW3183198709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.