ArticleHuman brain mapping2021
Increased functional interaction within frontoparietal network during working memory task in major depressive disorder.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Heterogeneous brain alterations in treatment-resistant depression converge on common control networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using AES-SDM.BMC psychiatry · 2026Pooled it
- Effects of working memory training on depressive symptoms: a systematic review and meta-analysis of randomized controlled trials.Translational psychiatry · 2026Pooled it
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using ALE.Psychological medicine · 2026Pooled it
- Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis.BMC psychiatry · 2025Pooled it
- Mama vs. Granny: An Exploratory fMRI Study on the Relative Roles of Female Caregivers in Children's Cognitive and Emotional Outcomes.Behavioral sciences (Basel, Switzerland) · 2026Article
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- The Effect of Comorbid Major Depressive Disorder on Working Memory in Young Adults With ADHD and the Mediating Role of the DLPFC.Alpha psychiatry · 2025Article
- Molecular Mechanisms Explaining Neuroanatomical Subtypes in Major Depressive Disorder: Insights From Cortical Morphometric Inverse Divergence.Human brain mapping · 2025Article
- The Left Insula Bridges Cognition, Emotion, and Brain Structure: A Multilayer Network Analysis of the Human Connectome Project-Young Adult.bioRxiv : the preprint server for biology · 2025Article
- Effects of different types of high-definition transcranial electrical stimulation on visual working memory and contralateral delayed activity.Journal of neuroengineering and rehabilitation · 2024Article
- Identifying EEG Biomarkers of Depression with Novel Explainable Deep Learning Architectures.bioRxiv : the preprint server for biology · 2024Article
- Alterations of functional brain activity and connectivity in female nurses working on long-term shift.Nursing open · 2024Article
- Repetitive Anodal TDCS to the Frontal Cortex Increases the P300 during Working Memory Processing.Brain sciences · 2022Article
- Increased functional interaction within frontoparietal network during working memory task in major depressive disorder.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal fronto-parietal activation has been suggested as a neural underpinning of the working memory (WM) deficits in major depressive disorder (MDD). However, the potential interaction within the frontoparietal network during WM processing in MDD remains unclear. This study aimed to examine the role of abnormal functional interactions within frontoparietal network in the neuropathological mechanisms of WM deficits in MDD. A total of 40 MDD patients and 47 demographic matched healthy controls (HCs) were included. Functional magnetic resonance imaging and behavioral data were collected during numeric n-back tasks. The psychophysiological interaction and dynamic causal modelling methods were applied to investigate the connectivity within the frontoparietal network in MDD during n-back tasks. The psychophysiological interaction analysis revealed that MDD patients showed increased functional connectivity between the right inferior parietal lobule (IPL) and the right dorsolateral prefrontal cortex (dlPFC) compared with HCs during the 2-back task. The dynamic causal modelling analysis revealed that MDD patients had significantly increased forward modulation connectivity from the right IPL to the right dlPFC than HCs during the 2-back task. Partial correlation was used to calculate the relationship between connective parameters and psychological variables in the MDD group, which showed that the effective connectivity from right IPL to right dlPFC was correlated negatively with the sensitivity index d' of WM performances and positively with the depressive severity in MDD group. In conclusion, the abnormal functional and effective connectivity between frontal and parietal regions might contribute to explain the neuropathological mechanism of working memory deficits in major depressive disorder.
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